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Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using copper benzenesulfonate as a reusable catalyst in aqueous solution

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Abstract

Copper benzenesulfonate was found to be an effective catalyst for one-pot three-component cyclocondensation of isatoic anhydride, aromatic aldehydes, and ammonium salts or primary amines in aqueous solution to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields. The catalyst is reusable and could be recycled for several times without distinct decrease in its efficiency.

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Acknowledgments

We are grateful to the Committee of Science and Technology of Liaoning Province of China for financial support (No. 20091001).

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Food Safety, Bohai University, Jinzhou, 121000, China

    Min Wang, Ting T. Zhang, Yan Liang & Jing J. Gao

Authors
  1. Min Wang
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  2. Ting T. Zhang
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  3. Yan Liang
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  4. Jing J. Gao
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Correspondence to Min Wang.

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Wang, M., Zhang, T.T., Liang, Y. et al. Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using copper benzenesulfonate as a reusable catalyst in aqueous solution. Monatsh Chem 143, 835–839 (2012). https://doi.org/10.1007/s00706-011-0648-6

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  • DOI: https://doi.org/10.1007/s00706-011-0648-6

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