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An efficient synthesis of β-aminoketone compounds through three-component Mannich reaction catalyzed by calcium chloride

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Abstract

Various β-aminoketones were synthesized in a three-component reaction of ketones, aldehydes, and amines in the presence of calcium chloride as catalyst in ethanol in high yields as compared to other synthetic methods. The advantages of this new method are a short reaction time (2 h), high yields, easy workup, convenience, low cost, and eco-friendly protocol.

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Authors and Affiliations

  1. School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431 606, Maharashtra, India

    Pramod Kulkarni, Balaji Totawar & Pudukulathan K. Zubaidha

Authors
  1. Pramod Kulkarni
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  2. Balaji Totawar
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  3. Pudukulathan K. Zubaidha
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Correspondence to Pudukulathan K. Zubaidha.

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Kulkarni, P., Totawar, B. & Zubaidha, P.K. An efficient synthesis of β-aminoketone compounds through three-component Mannich reaction catalyzed by calcium chloride. Monatsh Chem 143, 625–629 (2012). https://doi.org/10.1007/s00706-011-0609-0

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  • DOI: https://doi.org/10.1007/s00706-011-0609-0

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