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Green synthesis and characterization of novel α-acyloxycarboxamides through three-component reaction between pyridine carbaldehydes, cyclohexyl isocyanide, and benzoic acid derivatives

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Abstract

Novel α-acyloxycarboxamides were synthesized and characterized by the Passerini three-component reaction between pyridine carbaldehydes, cyclohexyl isocyanide, and benzoic acid derivatives in water. The reactions were carried out in one pot at room temperature with a quantitative yield. The products were obtained without any need for purification.

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Acknowledgments

The authors are thankful to the Payame Noor University for financial support of this research work.

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Authors and Affiliations

  1. Payame Noor University, Zanjan, Iran

    Esmail Vessally

  2. Chemistry Department, Zanjan University, P.O. Box 45195-313, Zanjan, Iran

    Ali Ramazani

  3. Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Elham Yaaghubi

Authors
  1. Esmail Vessally
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  2. Ali Ramazani
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  3. Elham Yaaghubi
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Correspondence to Esmail Vessally or Ali Ramazani.

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Vessally, E., Ramazani, A. & Yaaghubi, E. Green synthesis and characterization of novel α-acyloxycarboxamides through three-component reaction between pyridine carbaldehydes, cyclohexyl isocyanide, and benzoic acid derivatives. Monatsh Chem 142, 1143–1147 (2011). https://doi.org/10.1007/s00706-011-0536-0

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  • DOI: https://doi.org/10.1007/s00706-011-0536-0

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