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Synthesis and UV absorption of new conjugated quinoxaline 1,4-dioxide derivatives anticipated as tumor imaging and cytotoxic agents

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Abstract

New conjugated arylidine, enamine, and annelated pyrido derivatives of quinoxaline 1,4-dioxide were synthesized via utilization of an active allylic methyl group. Biodistribution studies were carried out by injecting a solution of an 125I derivative of an enamine-substituted quinoxaline 1,4-dioxide in normal and tumor-bearing mice. The uptake in solid tumor was over 6% of the injected dose per gram tissue body weight at 4 h post injection. These data revealed localization of the tracer in the tumor tissues with a high percentage sufficient to show a radiotherapeutic effect and showed that this is a promising tool for diagnosis. Also the radiotoxicity of the 125I-substituted compound on Ehrlich ascites carcinoma cells may encourage this behavior.

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Authors and Affiliations

  1. Faculty of Science (Damiatta), Chemistry Department, Mansoura University, Damiatta, Egypt

    Sameh R. El-Gogary, Mohamed A. Waly & Osama Z. El-Sepelgy

  2. Hot Laboratories Center, Atomic Energy Authority, Cairo, Egypt

    Ismail T. Ibrahim

Authors
  1. Sameh R. El-Gogary
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  2. Mohamed A. Waly
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  3. Ismail T. Ibrahim
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  4. Osama Z. El-Sepelgy
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Correspondence to Mohamed A. Waly.

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El-Gogary, S.R., Waly, M.A., Ibrahim, I.T. et al. Synthesis and UV absorption of new conjugated quinoxaline 1,4-dioxide derivatives anticipated as tumor imaging and cytotoxic agents. Monatsh Chem 141, 1253–1262 (2010). https://doi.org/10.1007/s00706-010-0386-1

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  • DOI: https://doi.org/10.1007/s00706-010-0386-1

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