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Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2

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Summary

Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, herpes simplex virus type 2 (HSV-2) did induce apoptosis in a small but significant fraction of the same cells. Apoptosis was not observed in Vero or HeLa cells infected with HSV-2. In addition, HSV-2 infection in the presence of cycloheximide induced extensive apoptosis of HEp-2 or HeLa cells.

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Authors and Affiliations

  1. Department of Virology, School of Medicine, The University of Tokushima, Tokushima, Japan, Japan

    A. H. Koyama, H. Akari & A. Adachi

  2. Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan, Japan

    F. Goshima & Y. Nishiyama

Authors
  1. A. H. Koyama
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  2. H. Akari
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  3. A. Adachi
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  4. F. Goshima
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  5. Y. Nishiyama
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Received June 9, 1998 Accepted July 15, 1998

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Koyama, A., Akari, H., Adachi, A. et al. Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2. Arch. Virol. 143, 2435–2441 (1998). https://doi.org/10.1007/s007050050473

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  • DOI: https://doi.org/10.1007/s007050050473

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