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Characterization of HIV-1 subtypes and transmitted drug resistance among treatment-naive HIV-infected individuals in Zhejiang, China, 2014-2017

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Abstract

In recent years, transmitted drug resistance (TDR) has adversely impacted upon first-line therapy for HIV-infected individuals. To understand the current subtype distribution and TDR level in Zhejiang, China we performed phylogenetic analysis and genotypic drug resistance testing of treatment-naive HIV-infected individuals. A total of 153 HIV-1 Pol genes were successfully amplified. The distribution of HIV-1 genotypes was as follows: CRF01_AE (43.8%); CRF07_BC (37.9%); subtype B/B’ (7.2%); CRF08_BC (5.2%); and others (5.9%). Drug resistance analysis demonstrated that 11.1% of isolates contained at least one NRTI or NNRTI resistance-associated mutations while 2.0% were identified to be resistant to PIs. These findings enhance our understanding of the genetic diversity of HIV-1 strains circulating in Zhejiang and provide some guidelines for HIV initial treatment therapy.

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Funding

This study was funded by Grants from the National High Technology Research and Development Program of China (863 Program, number of Grant: 2015AA020310).

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Authors and Affiliations

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China

    Yufan Xu, Xiaorong Peng, Xiuming Peng, Shujing Ji, Bin Chen, Liyan Wang, Xiangyun Lu, Tiansheng Xie, Tao Sun & Nanping Wu

  2. The Third People’s Hospital of Shenzhen, Shenzhen, 518112, China

    Hui Wang

Authors
  1. Yufan Xu
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  2. Xiaorong Peng
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  3. Xiuming Peng
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  4. Shujing Ji
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  5. Bin Chen
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  6. Liyan Wang
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  7. Xiangyun Lu
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  8. Tiansheng Xie
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  9. Tao Sun
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  10. Hui Wang
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  11. Nanping Wu
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Corresponding author

Correspondence to Nanping Wu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Institutional Ethics Committee of The First Affiliated Hospital, Medical College of Zhejiang University, China.

Informed consent

Signed informed consent was obtained from each patient before sample collection in this study.

Additional information

Handling Editor: Li Wu.

Electronic supplementary material

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Supplementary material 1 (DOC 438 kb)

Supplementary material 2 (DOC 65 kb)

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Xu, Y., Peng, X., Peng, X. et al. Characterization of HIV-1 subtypes and transmitted drug resistance among treatment-naive HIV-infected individuals in Zhejiang, China, 2014-2017. Arch Virol 163, 2233–2237 (2018). https://doi.org/10.1007/s00705-018-3839-1

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  • DOI: https://doi.org/10.1007/s00705-018-3839-1

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