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RETRACTED ARTICLE: Mitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virus

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This article was retracted on 29 November 2019

Abstract

To establish an association between mitochondrial dysfunction and apoptosis following infectious bronchitis virus (IBV) infection, HD11 avian macrophage cells were infected with the Massachusetts 41 (M41) strain. Our results show that the M41 strain of IBV induced cytopathic effects followed by the release of new viral particles. Elevated numbers of apoptotic cells were observed at 24, 48 and 72 h post-infection (p.i.). Viral infection was associated with mitochondrial membrane depolarization and reactive oxygen species (ROS) production at all of the examined timepoints p.i. In summary, IBV M41 replication in infected HD11 macrophages seems to induce mitochondrial bioenergy failure, acting as a respiratory chain uncoupler, without compromising viral replication.

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Acknowledgements

The authors thank the Fundação de Amparo à Pesquisa do Estado de São Paulo (Grants 2012/16715-6) for their support. TC Cardoso is recipient of CNPq (Brazilian Council for Research) fellowships and funding.

Author information

Authors and Affiliations

  1. Faculdade de Medicina Veterinária (FAMEV), Universidade Federal Uberlândia (UFU), Uberlândia, MG, Brazil

    Sergio E. L. da Silva

  2. Department of Veterinary Medicine, FZEA-USP-University of Sao Paulo, Pirassununga, SP, Brazil

    Helena L. Ferreira

  3. College of Veterinary Medicine, UNESP-University of São Paulo State, Araçatuba, SP, Brazil

    Felipe E. S. Silva, Roberto Gameiro, Carolina U. F. Fabri, Dielson S. Vieira & Tereza C. Cardoso

  4. Centro Universitário Católico Salesiano Auxilium, UniSLESIANO, Araçatuba, SP, Brazil

    Andrea F. Garcia

Authors
  1. Sergio E. L. da Silva
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  2. Helena L. Ferreira
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  3. Andrea F. Garcia
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  4. Felipe E. S. Silva
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  5. Roberto Gameiro
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  6. Carolina U. F. Fabri
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  7. Dielson S. Vieira
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  8. Tereza C. Cardoso
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Corresponding author

Correspondence to Tereza C. Cardoso.

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Funding

Fundação Amparo à Pesquisa Estado de São Paulo (grant 2012/16715-6).

Ethical approval

All applicable national (COBEA 2016/3456) for care and use animals were followed.

Conflict of interest

All authors declare no conflicts of interests.

Additional information

Handling Editor: Sheela Ramamoorthy.https://doi.org/10.1007/s00705-019-04481-w.

The Editor-in-Chief has retracted this article [1]. Figures 1A, 1D and 2B (bottom right) are identical with Figures 1A, 1H and 1B respectively in another article [2] which reports a study in a different species. In addition, Table 1 contains data presented in a third article [3], which also reports a study in a different species. The Editor-in-Chief therefore no longer has confidence in the validity of the data and the conclusions drawn. Tereza C. Cardoso disagrees with this retraction. Helena L. Ferreira agrees with this retraction. Sergio E. L. da Silva, Andrea F. Garcia, Felipe E. S. Silva, Roberto Gameiro, Carolina U. F. Fabri and Dielson S. Vieira have not responded to any correspondence about this retraction.

[1] da Silva, Sergio EL, et al. "Mitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virus." Archives of Virology 163.4 (2018): 1043-1049.

[2] Cardoso, Tereza C., et al. "Bovine Herpesvirus 5 promotes mitochondrial dysfunction in cultured bovine monocyte-derived macrophages and not affect virus replication." Veterinary Microbiology 229 (2019): 153-158.

[3] Garcia, Juliana Albarracin, et al. "Tumour necrosis factor‐alpha‐induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus." Veterinary and Comparative Oncology 15.2 (2017): 336-344.

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da Silva, S.E.L., Ferreira, H.L., Garcia, A.F. et al. RETRACTED ARTICLE: Mitochondrial bioenergy alterations in avian HD11 macrophages infected with infectious bronchitis virus. Arch Virol 163, 1043–1049 (2018). https://doi.org/10.1007/s00705-018-3704-2

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  • DOI: https://doi.org/10.1007/s00705-018-3704-2

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