Abstract
In this work, we studied seven groups of pregnant heifers from a consortium of dairy farms heavily infected with bovine leukemia virus (BLV). ELISA testing showed that the seroprevalence ranges of BLV in heifers between 36.1 and 66.5 %. No significant differences in proviral load were found when comparing heifers with adult cattle. Before their first delivery, more than 9.8 % of heifers show a high proviral load. Because BLV infection can occur during the first two years of life, the rationale of any strategy should be to take action as early as possible after birth.
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References
Gutiérrez G, Carignano H, Alvarez I, Martinez C, Porta N, Politzki R, Gammella M, Lomónaco M, Fondevila N, Poli M, Trono K (2012) Bovine leukemia virus p24 antibodies reflect blood proviral load. BMC Vet Res 8:187. doi:10.1186/1746-6148-8-187
Walsh RB, Kelton DF, Hietala SK, Duffield TF (2013) Evaluation of enzyme-linked immunosorbent assays performed on milk and serum samples for detection of neosporosis and leukosis in lactating dairy cows. Can Vet J 54:347–352
Bartlett PC, Sordillo LM, Byrem TM, Norby B, Grooms DL, Swenson CL, Zalucha J, Erskine RJ (2014) Options for the control of bovine leukemia virus in dairy cattle. J Am Vet Med Assoc 244:914–922. doi:10.2460/javma.244.8.914
Castellano A, Goizueta M (2014) Valor agregado institucional: Captación de valor económico de innovaciones tecnológicas. Asociación Argentina de Economía Agraria. http://inta.gob.ar/sites/default/files/script-tmp-inta_captacion_valor_economico_de_innovaciones_tecnol.pdf. Accessed 3 Feb 2016
Ott SL, Johnson R, Wells SJ (2003) Association between bovine-leukosis virus seroprevalence and herd-level productivity on US dairy farms. Prev Vet Med 61:249–262. doi:10.1016/j.prevetmed.2003.08.003
Gutiérrez G, Alvarez I, Merlini R, Rondelli F, Trono K (2014) Dynamics of perinatal bovine leukemia virus infection. BMC Vet Res 10:82. doi:10.1186/1746-6148-10-82
Gutiérrez G, Alvarez I, Politzki R, Lomónaco M, Dus Santos MJ, Rondelli F, Fondevila N, Trono K (2011) Natural progression of Bovine Leukemia Virus infection in Argentinean dairy cattle. Vet Microbiol 151:255–263. doi:10.1016/j.vetmic.2011.03.035
Trono KG, Pérez-Filgueira DM, Duffy S, Borca MV, Carrillo C (2001) Seroprevalence of bovine leukemia virus in dairy cattle in Argentina: comparison of sensitivity and specificity of different detection methods. Vet Microbiol 83:235–248. doi:10.1016/S0378-1135(01)00420-5
Lomónaco M, Alvarez I, Martínez C, Porta N, Merlini R, Carignano H, Gutiérrez G, Trono K (2014) Epidemiological features of BLV natural infection. Retrovirology 11(Suppl 1):P45. doi:10.1186/1742-4690-11-S1-P45
Gillet NA, Gutiérrez G, Rodriguez SM, De Brogniez A, Renotte N, Alvarez I, Trono K, Willems L (2013) Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection. PLoS Pathog 9:e1003687. doi:10.1371/journal.ppat.1003687
Gutiérrez G, Lomónaco M, Alvarez I, Fernandez F, Trono K (2015) Characterization of colostrum from dams of BLV endemic dairy herds. Vet Microbiol 177:366–369. doi:10.1016/j.vetmic.2015.03.001
Buehring GC, Shen HM, Jensen HM, Jin DL, Hudes M, Block G (2015) Exposure to bovine leukemia virus is associated with breast cancer: a case–control study. PLoS One 10:e0134304. doi:10.1371/journal.pone.0134304
Achachi A, Florins A, Gillet N, Debacq C, Urbain P, Foutsop GM, Vandermeers F, Jasik A, Reichert M, Kerkhofs P, Lagneaux L, Burny A, Kettmann R, Willems L (2005) Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. Proc Natl Acad Sci USA 102:10309–10314. doi:10.1073/pnas.0504248102
Gutiérrez G, Rodriguez S, Vilor A, Gillet N, DeBrogniez A, Trono K, Willems L (2015) An efficient vaccine against bovine leukemia virus. Retrovirology 12(Suppl 1):P3. doi:10.1186/1742-4690-12-S1-P3
Acknowledgments
This work was financially supported by the project PAE 37143 ANPCyT-INTA, INTA AESA-203992, Laboratorio de Virus Adventicios (INTA) and Fundación ArgenINTA. G. Gutiérrez, I. Alvarez, J.P. Jaworski, M. Poli and K. Trono are researchers from “Instituto Nacional de Tecnología Agropecuaria” (INTA) and “Consejo Nacional de Investigaciones Científicas y Tecnicas” (CONICET). H. Carignano is supported by a fellowship from INTA. L. Willems received financial support from “Fonds National de la Recherche Scientifique” (FNRS), the Télévie, the Interuniversity Attraction Poles (IAP) Program “Virus-host interplay at the early phases of infection” BELVIR initiated by the Belgian Science Policy Office, the Belgian Foundation against Cancer (FBC), the “Centre anticancéreux près ULg” (CAC) and the “Fonds Léon Fredericq” (FLF), the “Agricultureislife” project of Gembloux Agrobiotech (GxABT) and the “ULg Fonds Spéciaux pour la Recherche”.
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The authors declare that they have no conflict of interest.
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The procedures for extraction and handling of samples were approved by the Institutional Committee for Care and Use of Experimental Animals of the National Institute of Agricultural Technology (CICUAE-INTA) under protocol number 35/2010 and followed the guidelines described in the institutional manual.
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R. Merlini and G. Gutiérrez contributed equally to this work
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Merlini, R., Gutiérrez, G., Alvarez, I. et al. Bovine leukemia virus becomes established in dairy herds before the first lactation. Arch Virol 161, 3215–3217 (2016). https://doi.org/10.1007/s00705-016-2973-x
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DOI: https://doi.org/10.1007/s00705-016-2973-x