Abstract
Combined active and passive immunization has been established to be an optimal strategy for rabies post-exposure prophylaxis (PEP). Prompt administration of vaccine and rabies immunoglobulin (RIG) can reliably prevent the disease. However, RIG is unavailable and unaffordable in the majority of cases. On the basis of a model experiment using hamsters, we demonstrated that vaccine injection at the wound site in the same manner as administration of RIG provided protective efficacy that was not inferior to the current optimal PEP, a combination of vaccination and RIG. Further study is needed to determine whether it can replace the use of RIG.
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Acknowledgments
This work was supported in part by the Thai Red Cross Society, the Research Chairman Grant and the Cluster and Program Management Office (CPMO), from the National Science and Technology Development Agency of Thailand. We thank Ms. Siriporn Ghai for the extensive editing of this manuscript.
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Morimoto, K., Khawplod, P., Sato, Y. et al. Rabies vaccination at a virus-inoculated site as an alternative option to rabies immunoglobulin. Arch Virol 161, 2537–2541 (2016). https://doi.org/10.1007/s00705-016-2916-6
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DOI: https://doi.org/10.1007/s00705-016-2916-6