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Molecular epidemiology of coxsackievirus type B1

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Abstract

Coxsackievirus type B1 (CVB1) has emerged globally as the predominant enterovirus serotype and is associated with epidemics of meningitis and chronic diseases. In this report, the phylogeny of CVB1 was studied based on the VP1 sequences of 11 North African isolates and 81 published sequences. All CVB1 isolates segregated into four distinct genogroups and 10 genotypes. Most of the identified genotypes of circulating CVB1 strains appear to have a strict geographical specificity. The North African strains were of a single genotype and probably evolved distinctly. Using a relaxed molecular clock model and three different population models (constant population, exponential growth and Bayesian skyline demographic models) in coalescent analysis using the BEAST program, the substitution rate in CVB1 varied between 6.95 × 10−3 and 7.37 × 10−3 substitutions/site/year in the VP1 region. This study permits better identification of circulating CVB1, which has become one of the most predominant enterovirus serotypes in humans.

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Acknowledgments

This work was supported by the Tunisian Ministry for High Education and Scientific Research, grant number LR11-IPT09. We acknowledge the collaboration and expertise of Dr. Kais Ghedira from the Bioinformatics and Mathematical Modelling Group-Laboratory of Medical Parasitology, Biotechnologies and Biomolecules, LR11-IPT06, Pasteur Institute of Tunis, Tunisia.

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Authors and Affiliations

  1. Faculty of Sciences of Bizerte, University of Carthage, Avenue de la République, Amilcar, BP77, 1054, Tunis, Tunisia

    Ichrak Abdelkhalek

  2. Laboratory of Clinical Virology, WHO Regional Reference Laboratory for Poliomyelitis and Measles, Institut Pasteur de Tunis, 13, Place Pasteur, BP74, 1002, Tunis-Belvédère, Tunisia

    Ahlem Ben Yahia, Henda Touzi, Zina Meddeb, Henda Triki & Dorra Rezig

  3. University of Tunis El Manar, Campus universitaire Farhat Hached, Poste Romena, BP94, 1068, Tunis, Tunisia

    Ahlem Ben Yahia, Henda Touzi, Zina Meddeb, Henda Triki & Dorra Rezig

  4. Laboratory of Enteroviruses, Institut Pasteur of Algeria, Route de petit Staouéli, Dely Ibrahim, Algeria

    Mohamed Seghier

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  1. Ichrak Abdelkhalek
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  2. Mohamed Seghier
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Correspondence to Dorra Rezig.

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Abdelkhalek, I., Seghier, M., Yahia, A.B. et al. Molecular epidemiology of coxsackievirus type B1. Arch Virol 160, 2815–2821 (2015). https://doi.org/10.1007/s00705-015-2561-5

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  • DOI: https://doi.org/10.1007/s00705-015-2561-5

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