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Coxsackievirus A6 and enterovirus 71 causing hand, foot and mouth disease in Cuba, 2011–2013

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Abstract

Hand, foot and mouth disease (HFMD) is usually caused by coxsackievirus A16 or enterovirus 71 (EV71). Between 2011 and 2013, HFMD cases were reported from different Cuban provinces. A total of 42 clinical specimens were obtained from 23 patients. Detection, identification and phylogenetic analysis of enterovirus-associated HFMD were carried out by virus isolation, specific enterovirus PCR and partial VP1 sequences. HEV was detected in 11 HFMD cases. Emerging genetic variants of coxsackievirus A6 and EV71 were identified as the causative agents of the Cuban HFMD cases.

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Acknowledgments

We thank the patients, parents and physicians for participation in this study. We acknowledge the assistance from Cuban Provincial Centers for Epidemiology, Hygiene and Microbiology from Cienfuegos and Sancti Spiritus provinces for collecting the samples. We also thank Dr. Lídice Bernardo for helpful comments, and Dr. Ondrej Mach for reviewing the manuscript. This study was supported by the Cuban Ministry of Health as part of an enterovirus surveillance system maintained by the National Enterovirus Laboratory at Tropical Medicine Institute “Pedro Kourí”.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. “Pedro Kourí” Tropical Medicine Institute, Avenida Novia del Mediodía KM 6 1/2, La Lisa, Marianao 13, P.O. Box 601, CP.11400, Havana, Cuba

    Magilé C. Fonseca, Luis Sarmiento, Sonia Resik, Yenisleidys Martínez, Lai Heng Hung, Luis Morier, Alexander Piñón, Odalys Valdéz, Vivian Kourí & Guelsys González

Authors
  1. Magilé C. Fonseca
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  2. Luis Sarmiento
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  3. Sonia Resik
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  4. Yenisleidys Martínez
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  5. Lai Heng Hung
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  6. Luis Morier
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  7. Alexander Piñón
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  8. Odalys Valdéz
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  9. Vivian Kourí
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  10. Guelsys González
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Corresponding author

Correspondence to Magilé C. Fonseca.

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Fonseca, M.C., Sarmiento, L., Resik, S. et al. Coxsackievirus A6 and enterovirus 71 causing hand, foot and mouth disease in Cuba, 2011–2013. Arch Virol 159, 2451–2455 (2014). https://doi.org/10.1007/s00705-014-2071-x

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  • DOI: https://doi.org/10.1007/s00705-014-2071-x

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