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Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China

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Abstract

To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.

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Acknowledgments

This study was supported by the National Infectious Disease Surveillance Program of the Ministry of Science and Technology of the People’s Republic of China (project no. 2012ZX10004201-003 and 2013ZX10004202), and the National Science and Technology Major Project for Creation of Major New Drugs (project no. 2013ZX09304101-006),and HFMD Surveillance Program of Qingdao Municipal Science and Technology Bureau (project no.08-2-1-1-nsh). We thank Dr. Dustin Yang for his critical comments and excellent editorial assistance.

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Authors and Affiliations

  1. Qingdao Center for Disease Control and Prevention, Qingdao, 266033, Shandong, People’s Republic of China

    Xiaolin Liu, Weisen Yu, Qing Chai, Hui Wang, Weidong Wang, Lijuan Wang & Zhaoguo Wang

  2. National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Room 607, Beijing, 102206, People’s Republic of China

    Naiying Mao & Wenbo Xu

Authors
  1. Xiaolin Liu
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  2. Naiying Mao
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  3. Weisen Yu
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  4. Qing Chai
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  5. Hui Wang
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  6. Weidong Wang
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  7. Lijuan Wang
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  8. Zhaoguo Wang
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  9. Wenbo Xu
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Corresponding authors

Correspondence to Zhaoguo Wang or Wenbo Xu.

Additional information

X. Liu and N. Mao contributed equally to this work.

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Liu, X., Mao, N., Yu, W. et al. Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China. Arch Virol 159, 2497–2502 (2014). https://doi.org/10.1007/s00705-014-2067-6

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  • DOI: https://doi.org/10.1007/s00705-014-2067-6

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