Skip to main content

Advertisement

SpringerLink
Log in

Complete genome sequence analysis of two human enterovirus C99 strains isolated in Xinjiang Uighur Autonomous Region, China, in 2011

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Abstract

Human enterovirus C99 (EV-C99) is a new member of the species Enterovirus C, and although only a few EV-C99 sequences have been obtained thus far, the strain has been identified on four continents. In 2011, two EV-C99 strains were isolated from two healthy children in Xinjiang, China, and to our knowledge, this is the first finding of EV-C99 in China. The two strains, designated HT-XEBGH09F and KSSC-ALXHH01F, showed 78.8–86.6 % similarity to other EV-C99 strains and exhibited intra-serotypic genetic recombination within the P2 coding regions. These findings reflect high genetic divergence among the EV-C99 strains.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Apostol LN, Imagawa T, Suzuki A, Masago Y, Lupisan S, Olveda R, Saito M, Omura T, Oshitani H (2012) Genetic diversity and molecular characterization of enteroviruses from sewage-polluted urban and rural rivers in the Philippines. Virus Genes 45:207–217

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Bessaud M, Joffret ML, Holmblat B, Razafindratsimandresy R, Delpeyroux F (2011) Genetic relationship between co-circulating Human enteroviruses species C. PLoS One 6:e24823. doi:10.1371/journal.pone.0024823

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Bessaud M, Pillet S, Ibrahim W, Joffret ML, Pozzetto B, Delpeyroux F, Gouandjika-Vasilache I (2012) Molecular characterization of human enteroviruses in the Central African Republic: uncovering wide diversity and identification of a new human enterovirus A71 genogroup. J Clin Microbiol 50:1650–1658

    Article  PubMed Central  PubMed  Google Scholar 

  4. Brown BA, Maher K, Flemister MR, Naraghi-Arani P, Uddin M, Oberste MS, Pallansch MA (2009) Resolving ambiguities in genetic typing of human enterovirus species C clinical isolates and identification of enterovirus 96, 99 and 102. J Gen Virol 90:1713–1723

    Article  CAS  PubMed  Google Scholar 

  5. Cabrerizo M, Rabella N, Torner N, Castellanos T, Bustillo I, Varela C, Colomer J, Trallero G (2012) Molecular identification of an enterovirus 99 strain in Spain. Arch Virol 157:551–554

    Article  CAS  PubMed  Google Scholar 

  6. Daleno C, Greenberg D, Piralla A, Scala A, Baldanti F, Principi N, Esposito S (2013) A novel human enterovirus C (EV-C118) identified in two children hospitalised because of acute otitis media and community-acquired pneumonia in Israel. J Clin Virol 56:159–162

    Article  CAS  PubMed  Google Scholar 

  7. Khetsuriani N, Helfand R, Pallansch M, Kew O, Fowlkes A, Oberste MS, Tukei P, Muli J, Makokha E, Gary H (2009) Limited duration of vaccine poliovirus and other enterovirus excretion among human immunodeficiency virus infected children in Kenya. BMC Infect Dis 9:136

    Article  PubMed Central  PubMed  Google Scholar 

  8. Knowles NJ, Hovi T, Hyypiä T, King AMQ, Lindberg M, Pallansch MA, Palmenberg AC, Simmonds P, Skern T, Stanway G, Yamashita T, Zell R (2011) Picornaviridae. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ (eds) Virus taxonomy: classification and nomenclature of viruses: Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier, San Diego, pp 855–880

    Google Scholar 

  9. Oberste MS, Maher K, Kilpatrick DR, Pallansch MA (1999) Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification. J Virol 73:1941–1948

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Oberste MS, Feeroz MM, Maher K, Nix WA, Engel GA, Hasan KM, Begum S, Oh G, Chowdhury AH, Pallansch MA, Jones-Engel L (2013) Characterizing the picornavirus landscape among synanthropic nonhuman primates in Bangladesh, 2007 to 2008. J Virol 87:558–571

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Piralla A, Daleno C, Scala A, Greenberg D, Usonis V, Principi N, Baldanti F, Esposito S, Group C-P (2013) Genome characterisation of enteroviruses 117 and 118: a new group within human enterovirus species C. PLoS One 8:e60641

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Poyry TA, Hentze MW, Jackson RJ (2001) Construction of regulatable picornavirus IRESes as a test of current models of the mechanism of internal translation initiation. RNA 7:647–660

    Article  CAS  PubMed  Google Scholar 

  13. Rao DC, Ananda Babu M, Raghavendra A, Dhananjaya D, Kumar S, Maiya PP (2013) Non-polio enteroviruses and their association with acute diarrhea in children in India. Infect Genet Evol 17C:153–161

    Article  Google Scholar 

  14. Salminen MO, Carr JK, Burke DS, McCutchan FE (1995) Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning. AIDS Res Hum Retroviruses 11:1423–1425

    Article  CAS  PubMed  Google Scholar 

  15. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S (2011) MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731–2739

    Article  CAS  PubMed  Google Scholar 

  16. WHO (2004) Polio laboratory manual, 4th edn. World Health Organization, Geneva, Switzerland

    Google Scholar 

  17. Xu A, Tao Z, Wang H, Zhang Y, Song L, Li Y, Liu G, Liu Y, Yang H, Fan Q, Ji F, Yang J, Feng L, Xu W, Zhao Z (2011) The complete genome analysis of two enterovirus 96 strains isolated in China in 2005 and 2009. Virus Genes 42:323–330

    Article  CAS  PubMed  Google Scholar 

  18. Yozwiak NL, Skewes-Cox P, Gordon A, Saborio S, Kuan G, Balmaseda A, Ganem D, Harris E, DeRisi JL (2010) Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua. J Virol 84:9047–9058

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, Wang DY, Ji F, Wang XJ, Gao YJ, Chen L, An HQ, Li DX, Wang SW, Xu AQ, Wang ZJ, Xu WB (2009) An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol 44:262–267

    Article  PubMed  Google Scholar 

  20. Zhang Y, Zhang F, Zhu S, Chen L, Yan D, Wang D, Tang R, Zhu H, Hou X, An H, Zhang H, Xu W (2010) A Sabin 2-related poliovirus recombinant contains a homologous sequence of human enterovirus species C in the viral polymerase coding region. Arch Virol 155:197–205

    Article  CAS  PubMed  Google Scholar 

  21. Zhang Y, Zhu S, Yan D, Liu G, Bai R, Wang D, Chen L, Zhu H, An H, Kew O, Xu W (2010) Natural type 3/type 2 intertypic vaccine-related poliovirus recombinants with the first crossover sites within the VP1 capsid coding region. PLOS One 5:e15300

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by the National Natural Science Foundation of China (project nos. 30900063 and 81101303) and the National Key Technology R&D Program of China (project no. 2013ZX10004-202).

Conflict of interest

The authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. WHO WPRO Regional Polio Reference Laboratory and Ministry of Health Key Laboratory for Medical Virology, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, People’s Republic of China

    Qiang Sun, Yong Zhang, Shuangli Zhu, Xiaolei Li, Guohong Huang, Dongmei Yan, Dongyan Wang & Wenbo Xu

  2. Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention, Urumqi city, Xinjiang Uighur Autonomous Region, People’s Republic of China

    Hui Cui & Haishu Tang

Authors
  1. Qiang Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yong Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hui Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shuangli Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaolei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guohong Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Haishu Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Dongmei Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Dongyan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Wenbo Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yong Zhang or Wenbo Xu.

Additional information

Q. Sun, Y. Zhang and H. Cui contributed equally to this work and are co-first authors.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sun, Q., Zhang, Y., Cui, H. et al. Complete genome sequence analysis of two human enterovirus C99 strains isolated in Xinjiang Uighur Autonomous Region, China, in 2011. Arch Virol 159, 359–364 (2014). https://doi.org/10.1007/s00705-013-1839-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-013-1839-8

Keywords

Search

Navigation