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Analysis and characterization of the complete genome of a member of a new species of kobuvirus associated with swine

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Abstract

A virus belonging to a new species in the genus Kobuvirus, family Picornaviridae, was first isolated in 2008 from apparently healthy pigs in Hungary and China. We report the complete genome sequence and the genetic organization of the novel porcine kobuvirus strain Y-1-CHI, which was identified in China. The RNA genome of strain Y-1-CHI contains 8210 nucleotides (nt) and has an organization similar to that of other picornaviruses. The full-length nucleotide sequence of Y-1-CHI was 88.62%, 58.66%, and 48.86% identical to those of S-1-HUN, U-1, and Aichi virus, respectively. No positive results were found in 454 stool samples from children with acute gastroenteritis. Dendrograms indicated that Y-1-CHI and S-1-HUN are most closely related to each other and belong to the same species. Our results suggest that members of this novel species have the typical genome characteristics of members of the genus Kobuvirus and may be distributed globally in swine.

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Acknowledgments

This work was partly supported by China Mega-Project for Infectious Disease (2009ZX10004-001) and “973” National Key Basic Research Program of China (Grant No. 2007CB310500).

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None of the authors has a conflict of interest.

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Authors and Affiliations

  1. State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, People’s Republic of China

    Jie-mei Yu, Zi-qian Xu, Bo-wen Li, Qing Zhang, Shu-xian Cui, Miao Jin & Zhao-jun Duan

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  1. Jie-mei Yu
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  2. Zi-qian Xu
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  3. Bo-wen Li
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  4. Qing Zhang
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  5. Shu-xian Cui
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  6. Miao Jin
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  7. Zhao-jun Duan
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Correspondence to Zhao-jun Duan.

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Yu, Jm., Xu, Zq., Li, Bw. et al. Analysis and characterization of the complete genome of a member of a new species of kobuvirus associated with swine. Arch Virol 156, 747–751 (2011). https://doi.org/10.1007/s00705-010-0907-6

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  • DOI: https://doi.org/10.1007/s00705-010-0907-6

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