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Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5

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Abstract

Eighty-six varicella-zoster virus (VZV) strains of clades 1, 3 and 5, isolated from varicella and zoster patients in Germany, were analyzed by sequencing the glycoprotein E gene. Four novel non-synonymous and 10 novel synonymous mutations were detected. Of these, two synonymous (C513T, C885T) and two non-synonymous mutations (T485G, C524T) were located within the coding regions of e1 and c1. The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5.

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Acknowledgement

This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG, Germany).

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Authors and Affiliations

  1. Reference Laboratory for HSV and VZV, Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans-Knoell-Strasse 2, 07745, Jena, Germany

    Andreas Sauerbrei, Nadine Wiesener, Roland Zell & Peter Wutzler

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  1. Andreas Sauerbrei
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  2. Nadine Wiesener
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  3. Roland Zell
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  4. Peter Wutzler
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Correspondence to Andreas Sauerbrei.

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Sauerbrei, A., Wiesener, N., Zell, R. et al. Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5. Arch Virol 156, 505–509 (2011). https://doi.org/10.1007/s00705-010-0864-0

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  • DOI: https://doi.org/10.1007/s00705-010-0864-0

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