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Evolution of dengue virus in Mexico is characterized by frequent lineage replacement

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Abstract

Both dengue fever and its more serious clinical manifestation, dengue hemorrhagic fever, represent major public health concerns in the Americas. To understand the patterns and dynamics of virus transmission in Mexico, a country characterized by a marked increase in dengue incidence in recent years, we undertook a molecular evolutionary analysis of the largest sample of Mexican strains of dengue virus compiled to date. Our E gene data set comprises sequences sampled over a period of 27 years and representing all of the Mexican states that are endemic for dengue. Our phylogenetic analysis reveals that, for each of the four dengue viruses (DENV-1 to DENV-4), there have been multiple introductions of viral lineages in Mexico, with viruses similar to those observed throughout the Americas, but there has been strikingly little co-circulation. Rather, dengue virus evolution in Mexico is typified by frequent lineage replacement, such that only a single viral lineage dominates in a specific serotype at a specific time point. Most lineage replacement events involve members of the same viral genotype, although a replacement event involving different genotypes was observed with DENV-2, and viral lineages that are new to Mexico are described for DENV-1, DENV-3 and DENV-4.

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Acknowledgments

The authors wish to thank Ms. Silvia Tenorio-Salgado for technical assistance. This work was supported by a grant FOSSIS-CONACYT SALUD-2005-01-13852 to JRC.

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Authors and Affiliations

  1. Centro de Investigaciones Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Av. Universidad 655, Santa María Ahuacatitlan, 621000, Cuernavaca, Morelos, México

    Erik Carrillo-Valenzo & José Ramos-Castañeda

  2. Departamento de Epidemiología, Servicios de Salud de Morelos, Cuernavaca, Morelos, México

    Erik Carrillo-Valenzo

  3. Centro Regional de Investigaciones en Salud Pública, Instituto Nacional de Salud Pública, Tapachula, Chiapas, México

    Rogelio Danis-Lozano

  4. Programa en Matemáticas Aplicadas y Computación, Instituto Mexicano del Petroleo, México D.F., México

    Jorge X. Velasco-Hernández

  5. Unidad de Investigación Médica, CMN Ignacio García Téllez, Instituto Mexicano del Seguro Social, Mérida, Yucatán, México

    Gilma Sánchez-Burgos

  6. Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaria de Salud, México D.F., México

    Celia Alpuche, Irma López & Claudia Rosales

  7. Unité des Virus Emergents, Université de la Méditerranée, Marseille, France

    Cécile Baronti & Xavier de Lamballerie

  8. Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA

    Edward C. Holmes

Authors
  1. Erik Carrillo-Valenzo
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  2. Rogelio Danis-Lozano
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  3. Jorge X. Velasco-Hernández
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  4. Gilma Sánchez-Burgos
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  5. Celia Alpuche
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  6. Irma López
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  7. Claudia Rosales
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  8. Cécile Baronti
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  9. Xavier de Lamballerie
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  10. Edward C. Holmes
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  11. José Ramos-Castañeda
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Corresponding author

Correspondence to José Ramos-Castañeda.

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Carrillo-Valenzo, E., Danis-Lozano, R., Velasco-Hernández, J.X. et al. Evolution of dengue virus in Mexico is characterized by frequent lineage replacement. Arch Virol 155, 1401–1412 (2010). https://doi.org/10.1007/s00705-010-0721-1

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  • DOI: https://doi.org/10.1007/s00705-010-0721-1

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