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The complete genome sequence and molecular analysis of human hepatitis E virus genotype IV identified from a Korean patient

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Abstract

Hepatitis E virus (HEV) was originally identified as the etiological agent of non-HAV enterically transmitted hepatitis. One HEV strain (FJ763142) was identified from an acute viral hepatitis E patient with IgM anti-HEV in Korea. The complete genome sequence consisted of 7,238 nucleotides (nt) plus a 22-nt poly(A) tail. The strain belongs to genotype IV, with 91% homology compared with AB197674, which was found in a Japanese patient who had traveled to China. This finding suggests that HEV genotype IV already circulates in Korea, and this HEV might be the first example of an indigenous strain.

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Acknowledgments

This work was supported by Korea National Institute of Health (KNIH; Intramural Fund, Grant No. 4800-4863-300). The authors are grateful to Drs. Mishiro and Takahashi for designing primers to analyze the full genome of Korean HEV.

Conflict of interest statement

None.

Author information

Authors and Affiliations

  1. Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, Korea National Institute of Health, Nokbun-dong, Eunpyung-gu, Seoul, 122-701, Republic of Korea

    Haesun Yun, Jin Seon Kim & Hyeok Jin Lee

  2. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

    Sook Hyang Jeong & Jeong Sim Kim

  3. Department of Internal Medicine, Daejin Medical Center, Bundang Jesaeng General Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

    Sang Jong Park

  4. Department of Internal Medicine, Pochon CHA University Bundang CHA Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

    Seong Gyu Hwang

  5. Department of Internal Medicine, Seongnam Central Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

    Sook Kyoung Kang

  6. Expanded Programme on Immunization, Western Pacific Regional Office, World Health Organization, Manila, Philippines

    Youngmee Jee

  7. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Suwon-si, Gyeonggi-do, Republic of Korea

    Jong Hyun Kim

Authors
  1. Haesun Yun
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  2. Jin Seon Kim
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  3. Hyeok Jin Lee
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  4. Sook Hyang Jeong
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  5. Jeong Sim Kim
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  7. Seong Gyu Hwang
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  8. Sook Kyoung Kang
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  9. Youngmee Jee
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  10. Jong Hyun Kim
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Corresponding author

Correspondence to Haesun Yun.

Additional information

GenBank accession numbers: KNIH-hHEV4: FJ763142, KNIH-hHEV4-ORF1: EU849133, KNIH-hHEV4-ORF2: EU849134

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Yun, H., Kim, J.S., Lee, H.J. et al. The complete genome sequence and molecular analysis of human hepatitis E virus genotype IV identified from a Korean patient. Arch Virol 155, 1003–1008 (2010). https://doi.org/10.1007/s00705-010-0661-9

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  • DOI: https://doi.org/10.1007/s00705-010-0661-9

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