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Anti-influenza-virus activity of total alkaloids from Commelina communis L.

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Abstract

The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.

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Acknowledgments

This work was supported by research grants 2007ABA055 from the State Key Laboratory of Virology, Wuhan University.

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Authors and Affiliations

  1. Key Laboratory of TCM Resource and Compound Prescription, Ministry of Education, Hubei College of Traditional Chinese Medicine, 430065, Wuhan, China

    Fei-Hong Bing

  2. School of Pharmacy, Hubei College of Traditional Chinese Medicine, 430065, Wuhan, China

    Fei-Hong Bing, Zhi Li, Guo-Bin Zhang, Yi-Fan Liao & Jing Li

  3. State Key Laboratory of Virology, Institute of Virology, Wuhan University, 430072, Wuhan, China

    Jun Liu & Chang-Yuan Dong

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  1. Fei-Hong Bing
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  2. Jun Liu
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Correspondence to Fei-Hong Bing.

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F.-H. Bing and J. Liu contributed equally.

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Bing, FH., Liu, J., Li, Z. et al. Anti-influenza-virus activity of total alkaloids from Commelina communis L.. Arch Virol 154, 1837–1840 (2009). https://doi.org/10.1007/s00705-009-0503-9

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  • DOI: https://doi.org/10.1007/s00705-009-0503-9

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