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Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

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Abstract

Enterovirus 71 (EV71) has emerged as a significant pathogen with potential to cause large outbreaks. Because little is known about its seroprevalence and molecular epidemiology in Germany, data for 1997–2007 are presented. Four hundred thirty-six sera from persons aging 10 months to 75 years were tested in a neutralisation test; 63.4% of pre-school children were seronegative, whereas about 75% of adults had antibodies to EV71. Phylogenetic analysis of 28 isolates associated with neurological or cutaneous manifestations showed that isolates belonging to genogroup C1 predominated in 2000–2005, followed by a change to genogroup C2 in 2006 and 2007. This shows the importance of monitoring the diversity of one of the most relevant neurotropic enteroviruses.

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Authors and Affiliations

  1. Robert Koch Institute, Nordufer 20, 13353, Berlin, Germany

    Sabine Diedrich, Anna Weinbrecht & Eckart Schreier

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  1. Sabine Diedrich
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  2. Anna Weinbrecht
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  3. Eckart Schreier
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Correspondence to Sabine Diedrich.

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Diedrich, S., Weinbrecht, A. & Schreier, E. Seroprevalence and molecular epidemiology of enterovirus 71 in Germany. Arch Virol 154, 1139–1142 (2009). https://doi.org/10.1007/s00705-009-0413-x

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  • DOI: https://doi.org/10.1007/s00705-009-0413-x

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