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Evidence of diversification of dengue virus type 3 genotype III in the South American region

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Abstract

In order to gain insight into the genetic variability of dengue virus type 3 (DENV-3) genotype III isolated in the Latin American region, phylogenetic analysis were carried out using envelope (E) gene sequences from 57 DENV-3 genotype III strains isolated in 11 Latin American countries. At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences.

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Acknowledgments

This work was supported by the International Atomic Energy Agency, through Project ARCAL LXXXII, (RLA/6/050). The authors would like to thank Programa de Desarrollo de Ciencias Básicas (PEDECIBA), Uruguay, for support. We would like to thank Dr. Aracely Alava and Dr. Carlos Mosquera, from Instituto Nacional de Higiene y Medicina Tropical “Leopoldo Izquieta Perez”, Guayaquil, Ecuador, for invaluable help and support. We acknowledge anonymous reviewers for interesting comments to improve this work.

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Authors and Affiliations

  1. Instituto Nacional de Higiene y Medicina Tropical “Leopoldo Inquieta Perez”, Julian Coronel 905 y Esmeraldas, Guayaquil, Ecuador

    Domenica de Mora & Mary Regato

  2. Laboratorio de Virología Molecular, Facultad de Ciencias, Centro de Investigaciones Nucleares, Igua 4225, 11400, Montevideo, Uruguay

    Lucía D’ Andrea, Macarena Alvarez, Alvaro Fajardo, Ricardo Recarey, Rodney Colina & Juan Cristina

  3. Division of Human Health, International Atomic Energy Agency, Wagramerstrasse 5, 1400, Vienna, Austria

    Baldip Khan

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  1. Domenica de Mora
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  2. Lucía D’ Andrea
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  4. Mary Regato
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  8. Baldip Khan
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  9. Juan Cristina
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Corresponding author

Correspondence to Juan Cristina.

Additional information

Nucleotide sequence data reported are available in the EMBL database under accessions numbers FM246466 through FM246471 and FM246473.

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de Mora, D., Andrea, L.D., Alvarez, M. et al. Evidence of diversification of dengue virus type 3 genotype III in the South American region. Arch Virol 154, 699–707 (2009). https://doi.org/10.1007/s00705-009-0343-7

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  • DOI: https://doi.org/10.1007/s00705-009-0343-7

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