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Molecular characterization of hepatitis B virus genotype A from Argentina and Brazil

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Abstract

To study the diversification of hepatitis B virus genotype A in Latin America, we analyzed seven new Argentinian isolates and published sequences from Argentina and Brazil and other countries from the region. We found that the European subgenotype A2 prevailed in most of the countries except for Brazil, where the African subgenotype A1 predominated. A2 isolates did not differ significantly from the GenBank sequences, whereas some A1 isolates carried, concomitantly, amino acids characteristic of the subgenotypes A3 (R501 in P protein) and A2 (D355 in P/T54 in preS2). This combination is absent in the A1 subgenotype around the world. We discuss the origin, distribution and introduction of those subgenotypes in the Americas.

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Acknowledgments

This work was supported by grants from the University of Buenos Aires, the Consejo Nacional de Investigaciones Científicas y Técnicas and the Agencia Nacional de Promoción Científica y Tecnológica. The authors are grateful to Lic. María Victoria González Eusevi for language supervision.

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Authors and Affiliations

  1. Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4º piso, C1113AAB, Ciudad Autónoma de Buenos Aires, Argentina

    Viviana Andrea Mbayed, Flavia Guadalupe Piñeiro y Leone, Silvana Claudia Pezzano & Rodolfo Héctor Campos

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  1. Viviana Andrea Mbayed
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  2. Flavia Guadalupe Piñeiro y Leone
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  3. Silvana Claudia Pezzano
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  4. Rodolfo Héctor Campos
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Correspondence to Viviana Andrea Mbayed.

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Mbayed, V.A., Piñeiro y Leone, F.G., Pezzano, S.C. et al. Molecular characterization of hepatitis B virus genotype A from Argentina and Brazil. Arch Virol 154, 525–529 (2009). https://doi.org/10.1007/s00705-009-0328-6

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  • DOI: https://doi.org/10.1007/s00705-009-0328-6

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