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Evidence for recombination in the major capsid gene VP60 of the rabbit haemorrhagic disease virus (RHDV)

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Summary

Rabbit haemorrhagic disease (RHD) is a highly fatal disease caused by a virus of the family Caliciviridae. Whereas recombination is well documented in other members of this family, the extent of recombination has so far not been studied in RHDV. To reach a better evaluation of the possible role of recombination in the evolution of RHDV virulence, we have searched for recombination events in RHDV by analysing 43 complete sequences of the major capsid gene VP60. Phylogenetic analyses revealed two well separated groups. Clear evidence for recombination was found for the Hartmannsdorf strain which shows different phylogenetic profiles depending on the region of the capsid examined.

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Authors and Affiliations

  1. CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal

    J. Abrantes, P. J. Esteves & W. van der Loo

  2. Departamento de Zoologia e Antropologia, Faculdade de Ciências da Universidade do Porto, Porto, Portugal

    J. Abrantes & W. van der Loo

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  1. J. Abrantes
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  2. P. J. Esteves
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  3. W. van der Loo
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Correspondence to P. J. Esteves.

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Correspondence: Pedro José Esteves, CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Rua Padre Armando Quintas, 4485-661 Vairão, Portugal

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Abrantes, J., Esteves, P. & van der Loo, W. Evidence for recombination in the major capsid gene VP60 of the rabbit haemorrhagic disease virus (RHDV). Arch Virol 153, 329–335 (2008). https://doi.org/10.1007/s00705-007-1084-0

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  • DOI: https://doi.org/10.1007/s00705-007-1084-0

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