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Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China

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Summary

A Bayesian phylogenetic analysis of eight separate gene segments indicated A/Swine/Shandong/2/2003 (H5N1), A/Swine/Shandong/na/2003 (H9N2), A/Swine/Shandong/nb/2003 (H9N2) and A/Swine/Shandong/nc/2005 (H9N2) probably represent two multiple reassortant lineages, that had not been described before, with genes coming from H5N1, H9N2 and other lineages from poultry in Asia. Amino acid motifs within the haemagglutinin sequence of A/Swine/Shandong/nb/2003 suggested it may be able to infect people, whereas the sequences of the other three isolates suggested they would not have had that capability. Our analysis emphasizes the need for a comprehensive study of the interactions between H5N1 and H9N2 viruses in Asia that includes sequencing and phylogenetic investigation.

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Authors and Affiliations

  1. Institute of Life Sciences, Taishan Medical College, Shandong Tai’an, China

    W. F. Shi, X. M. Zhao, M. F. Yang, N. N. Yang & Y. J. Cui

  2. Faculty of Science, School of Botany and Zoology, Australian National University, Canberra, Australia

    M. J. Gibbs

  3. Chinese Academy of Sciences, Institute of Zoology, Beijing, China

    Y. Z. Zhang & C. D. Zhu

  4. Department of Basic Medicine, Taishan Medical College, Shandong Tai’an, China

    Z. Zhang & X. Jin

  5. School of Public Health, Guangxi Medical University, Guangxi Nanning, China

    L. Ji

Authors
  1. W. F. Shi
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  2. M. J. Gibbs
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  3. Y. Z. Zhang
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  4. Z. Zhang
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  5. X. M. Zhao
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  6. X. Jin
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  7. C. D. Zhu
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  8. M. F. Yang
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  9. N. N. Yang
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  10. Y. J. Cui
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  11. L. Ji
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Corresponding authors

Correspondence to W. F. Shi or C. D. Zhu.

Additional information

Correspondence: Wei Feng Shi, Institute of Life Sciences, Taishan Medical College, Shandong Tai’an 271000, China.

Dr. Chao Dong Zhu, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

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Shi, W., Gibbs, M., Zhang, Y. et al. Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China. Arch Virol 153, 211–217 (2008). https://doi.org/10.1007/s00705-007-1083-1

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  • DOI: https://doi.org/10.1007/s00705-007-1083-1

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