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The chloroxoquinolinic derivative 6-chloro-1,4-dihydro-4-oxo-1-(β-D-ribofuranosyl) quinoline-3-carboxylic acid inhibits HSV-1 adsorption by impairing its adsorption on HVEM

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Summary

In this paper, we describe that the oxoquinolinic acid derivative (compound A) inhibited HSV-1 adsorption on Vero cells. This effect was achieved with an EC50 value of 10 ± 2.0 µM and with low cytotoxicity, since the CC50 value for compound A was >1000 µM. Moreover, we demonstrate for the first time that adsorption inhibition was due to the blockage of the interactions between HSV-1 and the cellular receptor herpes virus entry mediator (HVEM). These results show that compound A can prevent HSV-1 infection in Vero cells, encouraging further studies to determine at what level compound A inhibits HSV-1-HVEM interactions.

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Authors and Affiliations

  1. Laboratório de Virologia Molecular, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil

    T. M. L. Souza & I. C. P. P. Frugulhetti

  2. Laboratório de Nucleosídeos, Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil

    M. C. Bastos V. De Souza, V. F. Ferreira, C. V. B. Santos Canuto & I. Pereira Marques

  3. Laboratório de Estrutura e Regulação de Proteínas e ATPases, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    T. M. L. Souza & C. F. L. Fontes

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  1. T. M. L. Souza
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  2. M. C. Bastos V. De Souza
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  3. V. F. Ferreira
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  4. C. V. B. Santos Canuto
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  7. I. C. P. P. Frugulhetti
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Souza, T., De Souza, M., Ferreira, V. et al. The chloroxoquinolinic derivative 6-chloro-1,4-dihydro-4-oxo-1-(β-D-ribofuranosyl) quinoline-3-carboxylic acid inhibits HSV-1 adsorption by impairing its adsorption on HVEM. Arch Virol 152, 1417–1424 (2007). https://doi.org/10.1007/s00705-007-0960-y

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  • DOI: https://doi.org/10.1007/s00705-007-0960-y

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