Summary
This study describes a method used to determine the diversity of NoVs co-circulating in the community that consisted of the analysis of a limited number of strains collected from outbreaks occurring at different times of the NoV season. The diversity of twenty NoV strains collected from outbreaks occurring at the beginning of each NoV season (September) was compared to the diversity found in the middle (December) and at the end of the season (March). The method was validated through the characterisation of greater numbers of strains at times when novel genotypes or variants were detected. A total of 864 strains from outbreaks of gastroenteritis from the 2003/04, 2004/05 and 2005/06 seasons were genotyped, with the majority of outbreaks occurring in the UK.
There was a greater diversity of NoV genotypes at the beginning of two of the three seasons, 2003/04 and 2005/06, when compared to strains circulating at the end of the seasons, and GII-4 NoV strains predominated (>90%) at the end of each season. Data from this study also identified the co-circulation and differentiation of three major GII-4 variants (v2, v3, and v4). Detailed analysis of a larger number of strains throughout each season confirmed that variants emerged, became the predominant circulating strain and were ultimately replaced with another variant selected from a pool of variants. By June 2006, GII-4 v4 (Hu/NoV/Rhyl440/2005/UK) emerged as the predominant GII-4 strain, usurping the previous GII-4 v3 strain [Hu/NoV/Hunter284E/040/AU] to become the commonest co-circulating strain, in the UK in 2006.
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GK Adak SM Meakins H Yip BA Lopman SJ O’Brien (2005) ArticleTitleDisease risks from foods, England and Wales, 1996–2000 Emerg Infect Dis 11 365–372 Occurrence Handle15757549
E Domingo J Diez MA Martinez J Hernandez A Holguin B Borrego MG Mateu (1993) ArticleTitleNew observations on antigenic diversification of RNA viruses: antigenic variation is not dependent on immune system J Gen Virol 74 2039–2045 Occurrence Handle7691985 Occurrence Handle1:CAS:528:DyaK2cXktV2g Occurrence Handle10.1099/0022-1317-74-10-2039
MR Evans R Meldrum W Lane D Gardner CD Ribeiro CI Gallimore D Westmoreland (2002) ArticleTitleAn outbreak of viral gastroenteritis following environmental contamination at a concert hall Epidemiol Infect 129 355–360 Occurrence Handle12403111 Occurrence Handle10.1017/S0950268802007446 Occurrence Handle1:STN:280:DC%2BD38nktlyntg%3D%3D
CI Gallimore D Cubitt N du Plessis JJ Gray (2004) ArticleTitleAsymptomatic and symptomatic excretion of noroviruses during a hospital outbreak of gastroenteritis J Clin Microbiol 42 2271–2274 Occurrence Handle15131210 Occurrence Handle10.1128/JCM.42.5.2271-2274.2004
CI Gallimore D Cubitt A Richards JJ Gray (2004) ArticleTitleDiversity of enteric viruses detected in patients with gastroenteritis in a tertiary referral paediatric hospital J Med Virol 73 443–449 Occurrence Handle15170641 Occurrence Handle10.1002/jmv.20110 Occurrence Handle1:CAS:528:DC%2BD2cXlt1Kgt74%3D
CI Gallimore JS Cheesbrough K Lamden C Bingham JJ Gray (2005) ArticleTitleMultiple norovirus genotypes characterised from an oyster-associated outbreak of gastroenteritis Int J Food Microbiol 103 323–330 Occurrence Handle15967530 Occurrence Handle10.1016/j.ijfoodmicro.2005.02.003 Occurrence Handle1:CAS:528:DC%2BD2MXns1Sqtro%3D
CI Gallimore C Pipkin H Shrimpton AD Green Y Pickford C McCartney G Sutherland DWG Brown JJ Gray (2005) ArticleTitleDetection of multiple enteric viruses within a foodborne outbreak of gastroenteritis: an indication of the source of contamination Epidemiol Infect 134 41–47 Occurrence Handle10.1017/S0950268804003218
CI Gallimore C Taylor AR Gennery AJ Cant A Galloway M Iturriza-Gomara JJ Gray (2006) ArticleTitleEnvironmental monitoring for gastroenteric viruses in a primary immunodeficiency unit J Clin Microbiol 44 395–399 Occurrence Handle16455890 Occurrence Handle10.1128/JCM.44.2.395-399.2006
JJ Gray C Cunliff J Ball DY Graham U Desselberger MK Estes (1994) ArticleTitleDetection of immunoglobulin M IgM, IgA, and IgG Norwalk virus-specific antibodies by indirect enzyme-linked immunosorbant assay with baculovirus-expressed Norwalk virus capsid antigen in adult volunteers challenged with Norwalk virus J Clin Microbiol 32 3059–3063 Occurrence Handle7883902 Occurrence Handle1:STN:280:DyaK2M7ovF2ntA%3D%3D
JJ Gray J Green C Cunliffe C Gallimore JV Lee K Neal DWG Brown (1997) ArticleTitleMixed genogroup SRSV infections among a party of canoeists exposed to contaminated recreational water J Med Virol 52 425–429 Occurrence Handle9260692 Occurrence Handle10.1002/(SICI)1096-9071(199708)52:4<425::AID-JMV14>3.0.CO;2-F Occurrence Handle1:CAS:528:DyaK2sXls1SmsL0%3D
J Green PA Wright CI Gallimore O Mitchell P Morgan-Capner DWG Brown (1998) ArticleTitleThe role of environmental contamination with small round structured viruses in a hospital outbreak investigated by reverse-transcriptase polymerase chain reaction assay J Hosp Infect 39 39–45 Occurrence Handle9617683 Occurrence Handle10.1016/S0195-6701(98)90241-9 Occurrence Handle1:STN:280:DyaK1c3otVKktQ%3D%3D
KY Green T Ando MS Balayan T Berke IN Clarke MK Estes DO Matson S Nakata JD Neill MJ Studdert HJ Thiel (2000) ArticleTitleTaxonomy of the Caliciviruses J Infect Dis 181 S322–S330 Occurrence Handle10804145 Occurrence Handle10.1086/315591
M Ho SS Monroe S Stine D Cubitt RI Glass HP Madore PF Pinsky C Ashley EO Caul (1989) ArticleTitleViral gastroenteritis aboard a cruise ship Lancet 2 961–965 Occurrence Handle2571872 Occurrence Handle10.1016/S0140-6736(89)90964-1 Occurrence Handle1:STN:280:DyaK3c%2FhtlOntw%3D%3D
X Jiang E Turf E Hu E Barrett XM Dai S Monroe C Humphrey LK Pickering DO Matson (1996) ArticleTitleOutbreaks of gastroenteritis in elderly nursing homes and retirement facilities associated with human caliciviruses J Med Virol 50 335–341 Occurrence Handle8950691 Occurrence Handle10.1002/(SICI)1096-9071(199612)50:4<335::AID-JMV9>3.0.CO;2-9 Occurrence Handle1:STN:280:DyaK2s7gsl2qsw%3D%3D
T Kageyama S Kojima M Shinohara K Uchida S Fukushi FB Hoshino N Takeda K Katayama (2003) ArticleTitleBroadly reactive and highly sensitive assay for Norwalk-ike viruses based on real-time quantitative reverse transcription-PCR J Clin Microbiol 41 1548–1557 Occurrence Handle12682144 Occurrence Handle10.1128/JCM.41.4.1548-1557.2003 Occurrence Handle1:CAS:528:DC%2BD3sXjsVOnu7w%3D
JE Kaplan GW Gary RC Baron N Singh LB Schonberger R Feldman HB Greenberg (1982) ArticleTitleEpidemiology of Norwalk gastroenteritis and the role of Norwalk virus in outbreaks of acute nonbacterial gastroenteritis Ann Intern Med 96 756–761 Occurrence Handle6283977 Occurrence Handle1:STN:280:DyaL383ivFSksw%3D%3D
JE Kaplan LB Schonberger G Varano N Jackman J Bied GW Gary (1982) ArticleTitleAn outbreak of acute nonbacterial gastroenteritis in a nursing home. Demonstration of person-to-person transmission by temporal clustering of cases Am J Epidemiol 116 940–948 Occurrence Handle6293306 Occurrence Handle1:STN:280:DyaL3s%2FntFOrsw%3D%3D
S Kobayashi T Morishita T Yamashita K Sakae O Nishio T Miyake Y Ishihara S Isomura (1991) ArticleTitleA large outbreak of gastroenteritis associated with a small round structured virus among schoolchildren and teachers in Japan Epidemiol Infect 107 81–86 Occurrence Handle1879493 Occurrence Handle1:STN:280:DyaK3MzkvVWnuw%3D%3D Occurrence Handle10.1017/S0950268800048706
S Kojima T Kageyama S Fukushi FB Hoshino M Shinohara K Uchida K Natori N Takeda K Katayama (2002) ArticleTitleGenogroup-specific PCR primers for detection of Norwalk-like viruses J Virol Methods 100 107–114 Occurrence Handle11742657 Occurrence Handle10.1016/S0166-0934(01)00404-9 Occurrence Handle1:CAS:528:DC%2BD3MXovF2itrY%3D
JN Kuritsky MT Osterholm HB Greenberg JA Korlath JR Godes CW Hedberg JC Forfang AZ Kapikian JC McCullough KE White (1984) ArticleTitleNorwalk gastroenteritis: a community outbreak associated with bakery product consumption Ann Intern Med 100 519–521 Occurrence Handle6322631 Occurrence Handle1:STN:280:DyaL2c7lt1ajsw%3D%3D
D Lees (2000) ArticleTitleViruses and bivalve shellfish J Food Microbiol 59 81–116 Occurrence Handle10.1016/S0168-1605(00)00248-8 Occurrence Handle1:CAS:528:DC%2BD3cXktlKmtbw%3D
SA Levin J Dushoff JB Plotkin (2004) ArticleTitleEvolution and persistence of influenza A and other diseases Math Biosci 188 17–28 Occurrence Handle14766091 Occurrence Handle10.1016/j.mbs.2003.08.010
BA Lopman M Reacher C Gallimore GK Adak JJ Gray DW Brown (2003) ArticleTitleA summer time peak of “winter vomiting disease”: Surveillance of Noroviruses in England and Wales, 1995 to 2002 BMC Pub Health 3 1–4 Occurrence Handle10.1186/1471-2458-3-1
B Lopman H Vennema E Kohli P Pothier A Sanchez A Negredo J Buesa E Schreier M Reacher D Brown J Gray M Iturriza C Gallimore B Bottiger KO Hedlund M Torven CH von Bonsdorff L Maunula M Poljsak-Prijatelj J Zimsek G Reuter G Szucs B Melegh L Svennson Y van Duijnhoven M Koopmans (2004) ArticleTitleIncrease in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant Lancet 363 682–688 Occurrence Handle15001325 Occurrence Handle10.1016/S0140-6736(04)15641-9
PJ Marks IB Vipond D Carlisle D Deakin RE Fey EO Caul (2000) ArticleTitleEvidence for airborne transmission of Norwalk-like virus (NLV) in a hotel restaurant Epidemiol Infect 124 481–487 Occurrence Handle10982072 Occurrence Handle10.1017/S0950268899003805 Occurrence Handle1:STN:280:DC%2BD3cvjs1ehtA%3D%3D
UD Parashar L Dow RL Fankhauser CD Humphrey J Miller T Ando KS Williams CR Eddy JS Noel T Ingram JS Bresee SS Monroe RI Glass (1998) ArticleTitleAn outbreak of viral gastroenteritis associated with consumption of sandwiches: implications for the control of transmission by food handlers Epidemiol Infect 121 615–621 Occurrence Handle10030711 Occurrence Handle10.1017/S0950268898001150 Occurrence Handle1:STN:280:DyaK1M7ltlOrsA%3D%3D
DB Smith J McAllister C Casino P Simmonds (1997) ArticleTitleVirus ‘quasispecies’ making a mountain out of a molehill J Gen Virol 78 1511–1519 Occurrence Handle9225023 Occurrence Handle1:CAS:528:DyaK2sXktlWltrc%3D
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Gallimore, C., Iturriza-Gomara, M., Xerry, J. et al. Inter-seasonal diversity of norovirus genotypes: Emergence and selection of virus variants. Arch Virol 152, 1295–1303 (2007). https://doi.org/10.1007/s00705-007-0954-9
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DOI: https://doi.org/10.1007/s00705-007-0954-9