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Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties

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Summary.

In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these “house keeping” duties, the N protein performs interactive “ambassadorial” functions interfering with important regulatory pathways in the infected cells.

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  1. Department of Virology, Haartman Institute, University of Helsinki, Finland

    P. Kaukinen, A. Vaheri & A. Plyusnin

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  1. P. Kaukinen
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  2. A. Vaheri
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  3. A. Plyusnin
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Kaukinen, P., Vaheri, A. & Plyusnin, A. Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties. Arch Virol 150, 1693–1713 (2005). https://doi.org/10.1007/s00705-005-0555-4

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