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Analysis of genetic heterogeneity of hepatitis C viruses in Central America reveals a novel genetic lineage

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Summary.

 Hepatitis C virus (HCV) has high genomic variability and at least six different types have been reported. The genotypes distribution is currently unknown among HCV strains circulating in Central America. In order to study the degree of genetic variability of strains isolated in Costa Rica, sequence data obtained from the 5′ non coding region from 7 patients from Costa Rica were compared with published sequences from 57 strains of all types. The phylogenetic analysis revealed the existence of type 1 strains of a novel genetic lineage, recently described for some South American countries, and indicates an increasing diversification of HCV.

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Authors and Affiliations

  1. Laboratorio Clínico, Hospital San Juan de Dios, San José, Costa Rica, , , , , , CR

    M. San Román, L. Lezama & E. Rojas

  2. Departamento de Técnicas Nucleares Aplicadas, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay, , , , , , UY

    R. Colina, L. García, A. Carlos & J. Cristina

  3. Division of Human Health, International Atomic Energy Agency, Vienna, Austria, , , , , , AT

    B. Khan

Authors
  1. M. San Román
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  2. L. Lezama
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  3. E. Rojas
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  4. R. Colina
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  5. L. García
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  6. A. Carlos
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  7. B. Khan
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  8. J. Cristina
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Received March 5, 2002; accepted May 17, 2002

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San Román, M., Lezama, L., Rojas, E. et al. Analysis of genetic heterogeneity of hepatitis C viruses in Central America reveals a novel genetic lineage . Arch Virol 147, 2239–2246 (2002). https://doi.org/10.1007/s00705-002-0869-4

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  • DOI: https://doi.org/10.1007/s00705-002-0869-4

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