Summary.
Homocysteine levels and the frequency of heterozygous methylenetetrahydrofolate reductase (MTHFR) C677T mutation are increased in open-angle glaucoma. Since homocysteine can induce vascular injury, alterations in extracellular matrix remodelling, and neuronal cell death, these findings may have important implications for understanding glaucomatous optic neuropathy.
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Received September 20, 2002; accepted October 21, 2002
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ID="*" S.B. and A.J. contributed equally to this work
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Authors' address: Dr. S. Bleich, MD, Friedrich-Alexander-University of Erlangen-Nuremberg, Department of Psychiatry and Psychotherapy, Schwabachanlage 6–10, D-91054 Erlangen, Federal Republic of Germany, e-mail: stefan.bleich@psych.imed.uni-erlangen.de
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Bleich, S., Jünemann, A., von Ahsen, N. et al. Homocysteine and risk of open-angle glaucoma. J Neural Transm 109, 1499–1504 (2002). https://doi.org/10.1007/s007020200097
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DOI: https://doi.org/10.1007/s007020200097