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Stability of CSF metabolites measured by proton NMR

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Summary.

Analysis of cerebrospinal fluid (CSF) metabolites can provide data regarding CNS involvement in neurologic and psychiatric illness. However, there is lack of research into the effect of processing and storage of CSF specimens on the levels of metabolites analyzed. CSF specimens from 10 depressed patients were analyzed by proton NMR before and after 72 hours exposure to room temperature. No effect of exposure was found on myo-inositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (>50%) and increase in lactate, glutamine, creatine, and creatinine levels.

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Authors and Affiliations

  1. Neurophysics Laboratory, and, USA

    J. Levine, K. Panchalingam, R. J. McClure & J. W. Pettegrew

  2. Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A, USA

    J. Levine, K. Panchalingam, R. J. McClure, S. Gershon & J. W. Pettegrew

  3. Department of Psychiatry, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel, Israel

    J. Levine

Authors
  1. J. Levine
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  2. K. Panchalingam
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  3. R. J. McClure
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  4. S. Gershon
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  5. J. W. Pettegrew
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Received February 22, 2000; accepted March 9, 2000

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Levine, J., Panchalingam, K., McClure, R. et al. Stability of CSF metabolites measured by proton NMR . J Neural Transm 107, 843–848 (2000). https://doi.org/10.1007/s007020070064

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  • DOI: https://doi.org/10.1007/s007020070064

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