Summary.
The insertion/deletion polymorphism of the gene of angiotensin-converting enzyme (ACE) was investigated in a case-control study including 169 patients with suffering from either bipolar disorder type I or unipolar recurrent major depression (DSM-IV) and 169 healthy controls. No significant association was found with bipolar disorder type I or unipolar recurrent depression and the polymorphism of the ACE gene. A previously reported genetic association (Arinami et al., 1996) was not confirmed by the present study.
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Received October 29, 1999; accepted April 6, 2000
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Pauls, J., Bandelow, B., Rüther, E. et al. Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder. J Neural Transm 107, 1361–1366 (2000). https://doi.org/10.1007/s007020070023
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DOI: https://doi.org/10.1007/s007020070023