Summary.
It has been shown that NMDA receptor antagonists can inhibit both the development and expression of a decrease in the duration of L-DOPA action in rats rotating after unilateral lesion of the nigro-striatal dopaminergic system. Using this model we found that the low affinity NMDA receptor antagonist amantadine (50 mg/kg b.i.d.) attenuated both the expression and development of the shortening of duration of L-DOPA (25 mg/kg b.i.d.) action. Amantadine was most efficient when given both during the induction and expression phase. However, an additional interaction experiment demonstrated that acutely given amantadine also prolongs the duration of L-DOPA-induced rotations. Hence, only the effect on development of shortening of L-DOPA action can be regarded as specific for repetitive treatment mode. The data suggest that treatment with amantadine might have beneficial effects on response fluctuations produced by chronic L-DOPA treatment.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received April 14, 1998; accepted June 17, 1998
Rights and permissions
About this article
Cite this article
Karcz-Kubicha, M., Quack, G. & Danysz, W. Amantadine attenuates response alterations resulting from repetitive L-DOPA treatment in rats. J Neural Transm 105, 1229–1236 (1998). https://doi.org/10.1007/s007020050125
Issue Date:
DOI: https://doi.org/10.1007/s007020050125