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Parkinson’s disease pathogenesis from the viewpoint of small fish models

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Parkinson’s disease is a neurodegenerative disorder that involves movement discloses, degeneration of dopaminergic neurons, and presence of cytoplasmic inclusion bodies. Various animal models have been developed and small fish including zebrafish and medaka fish have recently been employed as a new model for Parkinson disease. In this review, we summarize fish models of Parkinson’s disease mainly using our own findings and explain two major hypotheses of PD: lysosome dysfunction theory and mitochondrial dysfunction theory. Finally, we discuss the potential for future application of small fish model.

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  1. Department of Neuroscience of Disease, Center for Transdisciplinary Research, Niigata University, Niigata, Japan

    Hideaki Matsui

  2. Brain Research Institute, Niigata University, Niigata, Japan

    Hideaki Matsui

  3. Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Ryosuke Takahashi

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  1. Hideaki Matsui
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  2. Ryosuke Takahashi
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Correspondence to Hideaki Matsui.

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Matsui, H., Takahashi, R. Parkinson’s disease pathogenesis from the viewpoint of small fish models. J Neural Transm 125, 25–33 (2018). https://doi.org/10.1007/s00702-017-1772-1

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  • DOI: https://doi.org/10.1007/s00702-017-1772-1

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