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Comparative analysis of speech impairment and upper limb motor dysfunction in Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

It is currently unknown whether speech and limb motor effectors in Parkinson’s disease (PD) are controlled by similar underlying brain processes. Based on computerized objective analysis, the aim of this study was to evaluate potential correlation between speech and mechanical tests of upper limb motor function. Speech and upper limb motor tests were performed in 22 PD patients and 22 healthy controls. Quantitative acoustic analyses of eight key speech dimensions of hypokinetic dysarthria, including quality of voice, sequential motion rates, consonant articulation, vowel articulation, average loudness, loudness variability, pitch variability, and number of pauses, were performed. Upper limb movements were assessed using the motor part of the Unified Parkinson’s Disease Rating Scale, contactless three-dimensional motion capture system, blinded expert evaluation, and the Purdue Pegboard Test. Significant relationships were observed between the quality of voice assessed by jitter and amplitude decrement of finger tapping (r = 0.61, p = 0.003), consonant articulation evaluated using voice onset time and expert rating of finger tapping (r = 0.60, p = 0.003), and number of pauses and Purdue Pegboard Test score (r = 0.60, p = 0.004). The current study supports the hypothesis that speech impairment in PD shares, at least partially, similar pathophysiological processes with limb motor dysfunction. Vocal fold vibration irregularities appeared to be influenced by mechanisms similar to amplitude decrement during repetitive limb movements. Consonant articulation deficits were associated with decreased manual dexterity and movement speed, likely reflecting fine motor control involvement in PD.

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Acknowledgements

This study was supported by the Ministry of Health of the Czech Republic, Grant Nos. 15-28038A and 16-28119A. All rights reserved.

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Authors and Affiliations

  1. Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic

    Jan Rusz, Tereza Tykalová & Michal Novotný

  2. Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Jan Rusz, Robert Jech & Evžen Růžička

  3. Department of Biomedical Informatics, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic

    Radim Krupička & Zoltán Szabó

  4. Department of Neurology, 2nd Faculty of Medicine and Motol University Hospital, Charles University, Prague, Czech Republic

    Kateřina Zárubová

Authors
  1. Jan Rusz
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  2. Tereza Tykalová
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  3. Radim Krupička
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  4. Kateřina Zárubová
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  5. Michal Novotný
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  6. Robert Jech
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  7. Zoltán Szabó
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  8. Evžen Růžička
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Correspondence to Evžen Růžička.

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Rusz, J., Tykalová, T., Krupička, R. et al. Comparative analysis of speech impairment and upper limb motor dysfunction in Parkinson’s disease. J Neural Transm 124, 463–470 (2017). https://doi.org/10.1007/s00702-016-1662-y

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  • DOI: https://doi.org/10.1007/s00702-016-1662-y

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