Abstract
Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer’s disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population consists of 1,133 LOAD patients and 1,159 controls. Our data demonstrate that TMEM106B and APOE interact to increase AD risk.
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Acknowledgments
We are grateful to all of the subjects who kindly agreed to participate in this study. This work was supported by grants from the National Natural Science Foundation of China (81000544, 81171209, 81371406).
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The authors declare no conflict of interest.
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R.-C. Lu and H. Wang should be regarded as co-first authors.
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Lu, RC., Wang, H., Tan, MS. et al. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese. J Neural Transm 121, 283–287 (2014). https://doi.org/10.1007/s00702-013-1106-x
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DOI: https://doi.org/10.1007/s00702-013-1106-x