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Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Movement disorders (MDs), particularly chorea, may be the presenting neurological complication of systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS), but the association is not often initially recognized. Current evidence suggests an autoimmune mechanism related to antiphospholipid antibodies in these two conditions, although the antigenic target within the central nervous system has not yet been identified. Based on a comprehensive review of the literature, this article summarizes the current knowledge on MDs in SLE and APS. A high index of suspicion is required to make an early diagnosis and initiate appropriate treatment to provide symptomatic relief and to prevent other systemic complications related to the autoimmune process.

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Acknowledgments

CB is supported by the Czech Ministry of Education, research project MSM0021620849, Grantove agentury UK 441611 Charles University in Prague and IGA MZ ČR NT/12288-5/2011.

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  1. Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, The Smith Tower, Suite 1801, 6550 Fannin, Houston, TX, 77030, USA

    José Fidel Baizabal-Carvallo & Joseph Jankovic

  2. Department of Neurology, 1st Faculty of Medicine, General University Hospital, Charles University in Prague, Prague, Czech Republic

    Cecilia Bonnet

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  1. José Fidel Baizabal-Carvallo
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  2. Cecilia Bonnet
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Correspondence to José Fidel Baizabal-Carvallo.

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Baizabal-Carvallo, J.F., Bonnet, C. & Jankovic, J. Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome. J Neural Transm 120, 1579–1589 (2013). https://doi.org/10.1007/s00702-013-1023-z

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