Abstract
As Parkinson disease (PD) may affect men and women differentially, we investigated gender differences in regional projection system integrity in 148 PD subjects (36 women, 112 men) using monoaminergic [11C]dihydrotetrabenazine and acetylcholinesterase [11C]PMP positron emission tomography. After controlling for age, disease duration, and Hoehn and Yahr score, men showed 5.9 % greater caudate dopaminergic denervation (p = 0.0018) and 5.8 % greater neocortical cholinergic denervation (p = 0.0097). No significant gender differences were seen in putaminal dopaminergic or thalamic cholinergic denervation.
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Acknowledgments
We would like to thank Jamie Miller, Christine Minderovic, Cyrus Sarosh, and Virginia Rogers for their help with study subject coordination. We would also like to express our sincere gratitude to all subjects for their participation. This study was supported by the Michael J. Fox Foundation, the Department of Veterans Affairs, NIH grants P01 NS015655 and R01 NS070856.
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Kotagal, V., Albin, R.L., Müller, M.L.T.M. et al. Gender differences in cholinergic and dopaminergic deficits in Parkinson disease. J Neural Transm 120, 1421–1424 (2013). https://doi.org/10.1007/s00702-013-1013-1
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DOI: https://doi.org/10.1007/s00702-013-1013-1