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Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains

  • Basic Neurosciences, Genetics and Immunology - Original Article
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Abstract

Parkinson’s disease (PD) arises from the loss of dopaminergic neurons in the substantia nigra. 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is well known to cause Parkinsonism in humans with neurotoxicity specific for dopaminergic neurons. The experience with MPTP supports the hypothesis that endogenous or xenobiotic neurotoxins are involved in the pathogenesis of PD in humans. In our study, 1-acetyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydro-isoquinoline (ADTIQ), a novel compound, was found in frozen human brain tissues. The formation of ADTIQ was demonstrated using dopamine and methylglyoxal under physiological conditions. Methylglyoxal is a by-product of glycolysis. ADTIQ and its precursors, dopamine and methylglyoxal, were detected in different regions of frozen human brains such as the substantia nigra, caudate nucleus, putamen, frontal cortex, and the cerebellum. A significant difference in ADTIQ levels between control and Parkinson’s patients was found; for instance, the ADTIQ level in putamen of PD patients was 0.76 ± 0.27 nmol/g compared to 0.10 ± 0.01 nmol/g in control. Our results might indicate that ADTIQ is possibly related to Parkinson’s disease.

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Abbreviations

ADTIQ:

1-Acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline

PD:

Parkinson’s disease

TIQs:

Tetrahydroisoquinolines

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Acknowledgments

This work was partially supported by the Ministry of Science and Technology of China (2008AA12A218 and 2009BAK59B01).

Conflict of interest

The authors declare that they have no actual or potential conflicts of interest.

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Authors and Affiliations

  1. School of Life Science, Beijing Institute of Technology, Beijing, 100081, China

    Yulin Deng, Yongqian Zhang, Yujuan Li, Shengyuan Xiao, Dewei Song, Hong Qing & Qin Li

  2. Division of Neurology, College of Medicine, University of Saskatchewan, Saskatoon, SK, S7N5E4, Canada

    Ali H. Rajput

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  1. Yulin Deng
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  2. Yongqian Zhang
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  3. Yujuan Li
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  4. Shengyuan Xiao
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  7. Qin Li
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  8. Ali H. Rajput
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Correspondence to Yulin Deng.

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Deng, Y., Zhang, Y., Li, Y. et al. Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains. J Neural Transm 119, 435–441 (2012). https://doi.org/10.1007/s00702-011-0724-4

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  • DOI: https://doi.org/10.1007/s00702-011-0724-4

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