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Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy

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Abstract

Angiogenesis has not been extensively studied in Parkinson’s disease (PD) despite being associated with other neurodegenerative disorders. Post-mortem human brain tissues were obtained from subjects with pathologically confirmed Parkinson’s disease (PD) and progressive supranuclear palsy (PSP), a rapidly progressing Parkinsonian-like disorder. Tissues were also obtained from subjects with incidental Lewy body disease (iLBD) who had Lewy bodies in the substantia nigra pars compacta (SNpc) but had not been diagnosed with PD, and age-matched controls without Lewy body pathology. The SNpc, putamen, locus ceruleus (LC) and midfrontal cortex were examined for integrin αvβ3, a marker for angiogenesis, along with vessel number and activated microglia. All parkinsonian syndromes had greater αvβ3 in the LC and the SNpc, while only PD and PSP subjects had elevated αvβ3 in the putamen compared to controls. PD and PSP subjects also had increases in microglia number and activation in the SNpc suggesting a link between inflammation and clinical disease. Microglia activation in iLBD subjects was limited to the LC, an area involved at an early stage of PD. Likewise, iLBD subjects did not differ from controls in αvβ3 staining in the putamen, a late area of involvement in PD. The presence of αvβ3 reactive vessels in PD and its syndromes is indicative of newly created vessels that have not likely developed the restrictive properties of the blood brain barrier. Such angiogenic vessels could contribute to neuroinflammation by failing to protect the parenchyma from peripheral immune cells and inflammatory or toxic factors in the peripheral circulation.

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Acknowledgments

This work was supported by RO1AI51619 (BH), K08AG000848 (JAS), P30AG10161 (JAS), R01AG15819 (JAS), NS052414 (PMC) and the Kenneth Douglas Foundation (PMC). We thank Dr. Sue Leurgans for her statistical expertise. We thank the nuns, priests, and brothers from the following groups participating in the Religious Orders Study: Archdiocesan priests of Chicago, Dubuque, and Milwaukee; Benedictine Monks, Lisle, IL, and Collegeville, MN; Benedictine Sisters of Erie, Erie, PA; Benedictine Sisters of the Sacred Heart, Lisle, IL; Capuchins, Appleton, WI; Christian Brothers, Chicago, IL, and Memphis, TN; Diocesan priests of Gary, IN; Dominicans, River Forest, IL; Felician Sisters, Chicago, IL; Franciscan Handmaids of Mary, New York, NY; Franciscans, Chicago, IL; Holy Spirit Missionary Sisters, Techny, IL; Maryknolls, Los Altos, CA and Maryknoll, NY; Norbertines, DePere, WI; Oblate Sisters of Providence, Baltimore, MD; Passionists, Chicago, IL; Presentation Sisters, Dubuque, BVM., IA; Servites, Chicago, IL; Sinsinawa Dominican Sisters, Chicago, IL, and Sinsinawa, WI; Sisters of Charity, B.V.M., Chicago, IL, and Dubuque, IA; Sisters of the Holy Family, New Orleans, LA; Sisters of the Holy Family of Nazareth, Des Plaines, IL; Sisters of Mercy of the Americas, Chicago and Aurora, IL, Erie, PA; Sisters of St. Benedict, St. Cloud and St. Joseph, MN; Sisters of St. Casimir, Chicago, IL; Sisters of St. Francis of Mary Immaculate, Joliet, IL; Sisters of St. Joseph of LaGrange, LaGrange Park, IL; Society of Divine Word, Techny, IL; Trappists, Gethsemani, KY, and Peosta, IA; Wheaton Franciscan Sisters, Wheaton, IL. We thank T. Colvin and J. Bach, Religious Orders Study Coordinators; data and analytic programmers, Karen Skish, and Yu Li for technical assistance and the Rush Alzheimer’s Disease Center laboratory staff.

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  1. Department of Pharmacology, Rush University, Cohn Research Building, 1735 W Harrison Suite 412, Chicago, IL, 60612, USA

    Brinda Desai Bradaric, Aditiben Patel, Paul M. Carvey & Bill Hendey

  2. Rush Alzheimer’s Disease Center, Rush University, Chicago, IL, 60612, USA

    Julie A. Schneider

  3. Department of Neurological Sciences, Rush University, Chicago, IL, 60612, USA

    Julie A. Schneider & Paul M. Carvey

  4. Department of Pathology, Rush University, Chicago, IL, 60612, USA

    Julie A. Schneider

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  1. Brinda Desai Bradaric
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Correspondence to Bill Hendey.

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Desai Bradaric, B., Patel, A., Schneider, J.A. et al. Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy. J Neural Transm 119, 59–71 (2012). https://doi.org/10.1007/s00702-011-0684-8

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