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Cerebrospinal fluid insulin during non-neurological surgery

  • Basic Neurosciences, Genetics and Immunology - Short communication
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Abstract

Insulin plays an important metabolic and transmitter role in the central nervous system, but few studies have investigated the relationship between central and peripheral insulin concentrations. 35 patients undergoing knee surgery had cerebrospinal fluid (CSF) samples drawn before, 3 h after, and in the morning following surgery. Serum insulin concentrations increased after surgery and CSF insulin concentrations changed in the same direction with far smaller amplitude. These results indicate that the blood–brain barrier protects the brain from stress-induced peripheral hormonal fluctuations.

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Authors and Affiliations

  1. Forensic Psychiatry, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Sara Bromander, Rolf Anckarsäter & Caroline E. Wass

  2. Department of Clinical Sciences, Division of Medicine, Lund University, Lund, Sweden

    Bo Ahrén

  3. Department of Clinical Neuroscience, Division of Social and Forensic Psychiatry, Karolinska Institutet, Stockholm, Sweden

    Marianne Kristiansson

  4. Neurochemistry, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Kaj Blennow & Henrik Zetterberg

  5. Physiology, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Agneta Holmäng

  6. Forensic Psychiatry, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Henrik Anckarsäter

Authors
  1. Sara Bromander
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  2. Rolf Anckarsäter
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  3. Bo Ahrén
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  4. Marianne Kristiansson
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  5. Kaj Blennow
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  6. Agneta Holmäng
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  7. Henrik Zetterberg
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  8. Henrik Anckarsäter
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  9. Caroline E. Wass
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Corresponding author

Correspondence to Caroline E. Wass.

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Bromander, S., Anckarsäter, R., Ahrén, B. et al. Cerebrospinal fluid insulin during non-neurological surgery. J Neural Transm 117, 1167–1170 (2010). https://doi.org/10.1007/s00702-010-0456-x

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  • DOI: https://doi.org/10.1007/s00702-010-0456-x

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