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Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia

  • Biological Psychiatry - Short Communication
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Abstract

Previous work suggests that the methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08–1.79). This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.

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References

  • Adler Nevo G, Meged S, Sela BA, Hanoch-Levi A, Hershko R, Weizman A, Allen NC (2006) Homocysteine levels in adolescent schizophrenia patients. Eur Neuropsychopharmacol 16:588–591

    Article  CAS  PubMed  Google Scholar 

  • Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L (2008) Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40:827–834

    Article  CAS  PubMed  Google Scholar 

  • Brown AS, Bottiglieri T, Schaefer CA, Quesenberry CP Jr, Liu L, Bresnahan M, Susser ES (2007) Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch Gen Psychiatry 64:31–39

    Article  CAS  PubMed  Google Scholar 

  • Feng LG, Song ZW, Xin F, Hu J (2009) Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: a Chinese Han population-based case-control study. Psychiatry Res 168:205–208

    Google Scholar 

  • Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP (2006) The human reelin gene: transcription factors (+), repressors (−) and the methylation switch (+/−) in schizophrenia. Pharmacol Ther 111:272–286

    Article  CAS  PubMed  Google Scholar 

  • Kunitachi S, Fujita Y, Ishima T, Kohno M, Horio M, Tanibuchi Y, Shirayama Y, Iyo M, Hashimoto K (2009) Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors. Brain Res 1279:189–196

    Article  CAS  PubMed  Google Scholar 

  • Labuda D, Krajinovic M, Sabbagh A, Infante-Rivard C, Sinnett D (2002) Parental genotypes in the risk of a complex disease. Am J Hum Genet 71:193–197

    Article  CAS  PubMed  Google Scholar 

  • Levine J, Stahl Z, Sela BA, Gavendo S, Ruderman V, Belmaker RH (2002) Elevated homocysteine levels in young male patients with schizophrenia. Am J Psychiatry 159:1790–1792

    Article  PubMed  Google Scholar 

  • Lipton SA, Kim WK, Choi YB, Kumar S, D’Emilia DM, Rayudu PV, Arnelle DR, Stamler JS (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proc Natl Acad Sci USA 94:5923–5928

    Article  CAS  PubMed  Google Scholar 

  • Markan S, Sachdeva M, Sehrawat BS, Kumari S, Jain S, Khullar M (2007) MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem 302:125–131

    Article  CAS  PubMed  Google Scholar 

  • Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M (2006) Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry 11:143–149

    Article  CAS  PubMed  Google Scholar 

  • Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15:97–98

    Article  CAS  PubMed  Google Scholar 

  • Shi J, Gershon ES, Liu C (2008) Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Schizophr Res 104:96–107

    Article  PubMed  Google Scholar 

  • Weisberg IS, Jacques PF, Selhub J, Bostom AG, Chen Z, Curtis Ellison R, Eckfeldt JH, Rozen R (2001) The 1298A → C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156:409–415

    Article  CAS  PubMed  Google Scholar 

  • Zhang C, Xie B, Fang Y, Cheng W, Du Y, Wang D, Yu S (2010) Influence of maternal MTHFR A1298C polymorphism on the risk in offspring of schizophrenia. Brain Res 1320:130–134

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors are very grateful to all participants. This work was supported by National Natural Science Foundation of China (30500181) and Shanghai Natural Science Foundation (10ZR1425700). We thank the three anonymous reviewers for their insightful comments.

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Authors and Affiliations

  1. Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 Wan Ping Nan Road, 200030, Shanghai, People’s Republic of China

    Chen Zhang, Bin Xie, Yasong Du, Wenhong Cheng, Yiru Fang & Shunying Yu

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  1. Chen Zhang
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  2. Bin Xie
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  3. Yasong Du
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  4. Wenhong Cheng
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  5. Yiru Fang
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  6. Shunying Yu
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Correspondence to Yiru Fang or Shunying Yu.

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Zhang, C., Xie, B., Du, Y. et al. Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia. J Neural Transm 117, 1115–1117 (2010). https://doi.org/10.1007/s00702-010-0442-3

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  • DOI: https://doi.org/10.1007/s00702-010-0442-3

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