Abstract
Little is known about hemispheric lateralization of subcortical structures. Here, we show a higher expression of the subunit NR2A of the NMDA receptor mRNA in the striatum and of vGluT1 mRNA in the cingulate cortex, in the left hemisphere compared to the right one. This suggests a lateralization of the glutamatergic cortico-subcortical system, at the level of postsynaptic receptors as well as at the level of corticostriatal projections. Such lateralization could play a role in asymmetric diseases like Parkinson’s disease.
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Acknowledgments
We thank Theres Lauterburg for her technical assistance. This work is supported by a grant from the Swiss Parkinson Foundation to A.K.L.
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Capper-Loup, C., Rebell, D. & Kaelin-Lang, A. Hemispheric lateralization of the corticostriatal glutamatergic system in the rat. J Neural Transm 116, 1053–1057 (2009). https://doi.org/10.1007/s00702-009-0265-2
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DOI: https://doi.org/10.1007/s00702-009-0265-2