Abstract
Bipolar disorder is known to be subject to maternal transmission. Mitochondrial DNA has been suggested as playing a role in the illness. NDUFV2, located on 18p11.31-p11.2, encodes an important subunit of mitochondrial NADH (complex I). Previous studies have reported the association of NDUFV2 with bipolar disorder in the Japanese and Caucasian populations. Whether it is also a susceptible gene in the Chinese population is unknown. To study the role of NDUFV2 in bipolar disorder in the Chinese population, 506 unrelated bipolar patients and 507 unrelated controls of Chinese Han origin were recruited. Six SNPs (rs11661859, rs6506640, rs1156044, rs4148965, rs906807, rs977581) were genotyped using either TaqMan® technology or direct sequencing. The haplotype consisting of rs6506640 (−342G > A) and rs906807 (86C > T) was found to be associated with bipolar disorder (global p = 0.012 before corrected, p = 0.030 after 10,000 permutations; individual p (A–T of rs6506640–rs906807) = 0.014 after 100,000 permutations (p = 0.0065 before corrected). The genotype frequency of rs906807 differed between bipolar female patients and female controls (p = 0.012, uncorrected). No other individual associations of SNPs with bipolar were detected. Our study indicated that the regions spanning from the promoter to the exon 2 may contain susceptible polymorphisms which predispose to bipolar disorder.
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Acknowledgments
This work was supported by grants from the National Natural Science Foundation of China, the national S973 and 863 Programs, the Shanghai Municipal Commission for Science and Technology (05JC14090), the Shanghai Leading Academic Discipline Project (B205), and the Shanghai Rising-Star Program (08QA14039). This work was also supported by grants (2006AA02A407, 2006CB910601, 2006BAI05A05, 2007CB947300 and 07DZ22917) and the cooperation program with Roche. We appreciate the contribution of all of the members participating in this Ethical Standards. The experiment was conducted in accordance with the Declaration of Helsinki. All participating subjects signed an informed consent that had been reviewed and approved by the Shanghai Ethics Committee of Human Genetic Resources study, as well as of the psychiatrists who helped us in the diagnosis.
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Jing Zhang and Xingwang Li contributed equally to this work.
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Zhang, J., Li, X., Wang, Y. et al. Association study on the mitochondrial gene NDUFV2 and bipolar disorder in the Chinese Han population. J Neural Transm 116, 357–361 (2009). https://doi.org/10.1007/s00702-009-0185-1
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DOI: https://doi.org/10.1007/s00702-009-0185-1