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Reduced number of taste papillae in patients with eating disorders

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Summary.

Taste affects dietary behavior and in turn taste response and food preferences are altered in eating disorders. Fungiform papillae on the tongue are the first line of the gustatory apparatus to provide information about taste. Aim of this study is determination of their number in patients with eating disorders. Twenty-seven female adolescents with eating disorders and 16 age-matched healthy female controls were examined. Tongues were stained with blue food coloring and the number of fungiform papillae was quantified using digital photography and image processing. Patients with restrictive type eating disorders showed a more distinct reduction (p < 0.001) of fungiform papillae than patients with vomiting and/or binge eating (p < 0.05), compared with those of healthy control subjects. Causes may be an initially disturbed development of fungiform papillae or secondary to changes in eating behavior which may be mutually causative.

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References

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders (DSM-IV), 2nd edn. of the German version 1998. Hogrefe, Göttingen Bern Toronto Seattle, pp 613–626

  • R Bakan CL Birmingham L Aeberhardt EM Goldner (1993) ArticleTitleDietary zinc intake of vegetarian and nonvegetarian patients with anorexia nervosa Int J Eat Disord 13 229–233 Occurrence Handle8477292 Occurrence Handle10.1002/1098-108X(199303)13:2<229::AID-EAT2260130211>3.0.CO;2-1 Occurrence Handle1:STN:280:DyaK3s3jsl2hsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • LM Bartoshuk (2000) ArticleTitleComparing sensory experiences across individuals: recent psychophysical advances illuminate genetic variation in taste perception Chem Senses 25 447–460 Occurrence Handle10944509 Occurrence Handle10.1093/chemse/25.4.447 Occurrence Handle1:STN:280:DC%2BD3cvisFCqsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • LM Bartoshuk VB Duffy IJ Miller (1994) ArticleTitlePTC/PROP tasting: anatomy, psychophysics, and sex effects Physiol Behav 56 1165–1171 Occurrence Handle7878086 Occurrence Handle10.1016/0031-9384(94)90361-1 Occurrence Handle1:CAS:528:DyaK2MXitlOgsrs%3D

    Article  PubMed  CAS  Google Scholar 

  • IL Bernstein S Borson (1986) ArticleTitleLearned food aversion: a component of anorexia syndromes Psychol Rev 93 462–472 Occurrence Handle3534918 Occurrence Handle10.1037/0033-295X.93.4.462 Occurrence Handle1:STN:280:DyaL2s%2FktFygsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • FA Catalanotto R Nanda (1977) ArticleTitleThe effects of feeding a zinc-deficient diet on taste acuity and tongue epithelium in rats J Oral Pathol 6 211–220 Occurrence Handle407339 Occurrence Handle10.1111/j.1600-0714.1977.tb01643.x Occurrence Handle1:CAS:528:DyaE2sXlsFSmsbk%3D

    Article  PubMed  CAS  Google Scholar 

  • LHH Cheng PP Robinson (1991) ArticleTitleThe distribution of fungiform papillae and taste buds on the human tongue Archs Oral Biol 36 583–589 Occurrence Handle10.1016/0003-9969(91)90108-7 Occurrence Handle1:STN:280:DyaK387ktlOisA%3D%3D

    Article  CAS  Google Scholar 

  • HC Chou CL Chien HL Huang KS Lu (2001) ArticleTitleEffects of zinc deficiency on the vallate papillae and taste buds in rats J Formos Med Assoc 100 326–335 Occurrence Handle11432312 Occurrence Handle1:CAS:528:DC%2BD3MXltV2ltr4%3D

    PubMed  CAS  Google Scholar 

  • P Cleaton-Jones (1976) ArticleTitleA denervation study of taste buds in the soft palate of the albino rat Arch Oral Biol 21 79–82 Occurrence Handle1064392 Occurrence Handle10.1016/0003-9969(76)90075-3 Occurrence Handle1:STN:280:DyaE283gsFakug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SR Crystal KL Teff (2006) ArticleTitleTasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eaters Physiol Behav 89 213–220 Occurrence Handle16846622 Occurrence Handle10.1016/j.physbeh.2006.06.013 Occurrence Handle1:CAS:528:DC%2BD28XovVSju7k%3D

    Article  PubMed  CAS  Google Scholar 

  • JF Delwiche Z Buletic PAS Breslin (2001) ArticleTitleRelationship of papillae number to bitter intensity of quinine and PROP within and between individuals Physiol Behav 74 329–337 Occurrence Handle11714496 Occurrence Handle10.1016/S0031-9384(01)00568-6 Occurrence Handle1:CAS:528:DC%2BD3MXosFOjsb0%3D

    Article  PubMed  CAS  Google Scholar 

  • D Dhouailly C Xu M Manabe A Schermer TT Sun (1989) ArticleTitleExpression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation Exp Cell Res 181 141–158 Occurrence Handle2465162 Occurrence Handle10.1016/0014-4827(89)90189-4 Occurrence Handle1:CAS:528:DyaL1MXhsFWltLk%3D

    Article  PubMed  CAS  Google Scholar 

  • A Drewnowski (1989) ArticleTitleTaste responsiveness in eating disorders Ann N Y Acad Sci 575 399–408 Occurrence Handle2699201 Occurrence Handle10.1111/j.1749-6632.1989.tb53260.x Occurrence Handle1:STN:280:DyaK3c3isFGgsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • A Drewnowski (1997) ArticleTitleTaste preference and food intake Annu Rev Nutr 17 237–253 Occurrence Handle9240927 Occurrence Handle10.1146/annurev.nutr.17.1.237 Occurrence Handle1:CAS:528:DyaK2sXkvFGmt7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • A Drewnowski KA Halmi B Pierce J Gibbs GP Smith (1987) ArticleTitleTaste and eating disorders Am J Clin Nutr 46 442–450 Occurrence Handle3630963 Occurrence Handle1:STN:280:DyaL2szitlSgtg%3D%3D

    PubMed  CAS  Google Scholar 

  • A Drewnowski C Hann (1999) ArticleTitleFood preferences and reported frequencies of food consumption as predictors of current diet in young women Am J Clin Nutr 70 28–36 Occurrence Handle10393135 Occurrence Handle1:CAS:528:DyaK1MXksVKgt74%3D

    PubMed  CAS  Google Scholar 

  • A Drewnowski SA Henderson A Levine C Hann (1999) ArticleTitleTaste and food preferences as predictors of dietary practices in young women Public Health Nutr 2 513–519 Occurrence Handle10656470 Occurrence Handle1:STN:280:DC%2BD3c7itValsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • C Dulac (2000) ArticleTitleThe physiology of taste, vintage 2000 Cell 100 607–610 Occurrence Handle10761926 Occurrence Handle10.1016/S0092-8674(00)80697-2 Occurrence Handle1:CAS:528:DC%2BD3cXitFeksrg%3D

    Article  PubMed  CAS  Google Scholar 

  • R Eiber I Berlin B Brettes de C Foulon JD Guelfi (2002) ArticleTitleHedonic response to sucrose solutions and the fear of weight gain in patients with eating disorders Psychiatr Res 113 173–180 Occurrence Handle10.1016/S0165-1781(02)00232-9

    Article  Google Scholar 

  • GK Essick A Chopra S Guest F McGlone (2003) ArticleTitleLingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects Physiol Behav 80 289–302 Occurrence Handle14637228 Occurrence Handle10.1016/j.physbeh.2003.08.007 Occurrence Handle1:CAS:528:DC%2BD3sXpt1Cjt7k%3D

    Article  PubMed  CAS  Google Scholar 

  • DL Franko BE Wolfe DC Jimerson (1994) ArticleTitleElevated sweet taste pleasantness ratings in bulimia nervosa Physiol Behav 56 969–973 Occurrence Handle7824599 Occurrence Handle10.1016/0031-9384(94)90331-X Occurrence Handle1:STN:280:DyaK2M7isFSlug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • TA Gilbertson (1998) ArticleTitleRole of the taste system in ingestive behavior Ann N Y Acad Sci 855 860–867 Occurrence Handle9929702 Occurrence Handle10.1111/j.1749-6632.1998.tb10676.x Occurrence Handle1:CAS:528:DyaK1MXmvFWgug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • JMH Hall ML Bell TE Finger (2003) ArticleTitleDisruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae Dev Biol 255 263–277 Occurrence Handle12648489 Occurrence Handle10.1016/S0012-1606(02)00048-9 Occurrence Handle1:CAS:528:DC%2BD3sXitFagtLs%3D

    Article  PubMed  CAS  Google Scholar 

  • CM Hadigan EJ Anderson KK Miller JL Hubbard DB Herzog A Klibanski SK Grinspoon (2000) ArticleTitleAssessment of macronutrient and micronutrient intake in women with anorexia nervosa Int J Eat Disord 28 284–292 Occurrence Handle10942914 Occurrence Handle10.1002/1098-108X(200011)28:3<284::AID-EAT5>3.0.CO;2-G Occurrence Handle1:STN:280:DC%2BD3cvotFSquw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • H Hamano K Yoshinaga R Eta Y Emori D Kawasaki Y Iino M Sawada H Kuroda M Takei (2006) ArticleTitleEffect of polaprezinc on taste disorders in zinc-deficient rats Biofactors 28 185–193 Occurrence Handle17473379 Occurrence Handle1:CAS:528:DC%2BD2sXksVCjtL0%3D

    PubMed  CAS  Google Scholar 

  • M Ikeda A Ikui H Tomita (2002) ArticleTitleGustatory function of the soft palate Acta Otolaryngol Suppl 546 69–73 Occurrence Handle12132623 Occurrence Handle10.1080/00016480260046436

    Article  PubMed  Google Scholar 

  • H-S Jung K Akita J-Y Kim (2004) ArticleTitleSpacing patterns on tongue surface-gustatory papilla Int J Dev Biol 48 157–161 Occurrence Handle15272380 Occurrence Handle10.1387/ijdb.15272380

    Article  PubMed  Google Scholar 

  • P Jirik-Babb JL Katz (1988) ArticleTitleImpairment of taste perception in anorexia nervosa and bulimia Int J Eat Disord 7 353–360 Occurrence Handle10.1002/1098-108X(198805)7:3<353::AID-EAT2260070306>3.0.CO;2-Y

    Article  Google Scholar 

  • F Karege M Schwald M Cisse (2002) ArticleTitlePostnatal developmental profile of the brain-derived neurotrophic factor in rat brain platelets Neurosci Lett 328 261–264 Occurrence Handle12147321 Occurrence Handle10.1016/S0304-3940(02)00529-3 Occurrence Handle1:CAS:528:DC%2BD38XlvVWitrs%3D

    Article  PubMed  CAS  Google Scholar 

  • JY Kim T Mochizuki K Akita HS Jung (2003) ArticleTitleMorphological evidence of the importance of epithelial tissue during mouse tongue development Exp Cell Res 290 217–226 Occurrence Handle14567981 Occurrence Handle10.1016/S0014-4827(03)00319-7 Occurrence Handle1:CAS:528:DC%2BD3sXotVCit7c%3D

    Article  PubMed  CAS  Google Scholar 

  • H Koizumi K Hashimoto K Itoh M Nakazato E Shimizu S Ohgake K Koike N Okamura S Matsushita K Suzuki M Murayama S Higuchi M Iyo (2004) ArticleTitleAssociation between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders Am J Med Genet B Neuropsychiatr Genet 127B 125–127 Occurrence Handle10.1002/ajmg.b.20153 Occurrence Handle15108194

    Article  PubMed  Google Scholar 

  • TVE Kral (2006) ArticleTitleEffects on hunger and satiety, perceived portion size and pleasantness of taste of varying the portion size of foods: a brief review of selected studies Appetite 46 103–105 Occurrence Handle16297500 Occurrence Handle10.1016/j.appet.2005.05.006

    Article  PubMed  Google Scholar 

  • A Kullaa-Mikkonen A Koponen A Seilonen (1987) ArticleTitleQuantitative study of human papillae and taste buds: variation with aging and in different morphological forms of the tongue Gerodontics 3 131–135 Occurrence Handle3476331 Occurrence Handle1:STN:280:DyaL2szgsFaluw%3D%3D

    PubMed  CAS  Google Scholar 

  • JH Lacey PA Stanley M Crutchfield AH Crisp (1977) ArticleTitleSucrose sensitivity in anorexia nervosa J Psychosom Res 21 17–21 Occurrence Handle853454 Occurrence Handle10.1016/0022-3999(77)90021-6 Occurrence Handle1:CAS:528:DyaE2sXhvVOisrk%3D

    Article  PubMed  CAS  Google Scholar 

  • B Lask A Fosson U Rolfe S Thomas (1993) ArticleTitleZinc deficiency and childhood-onset anorexia nervosa J Clin Psychiat 54 63–66 Occurrence Handle1:STN:280:DyaK3s7os1Ogtg%3D%3D

    CAS  Google Scholar 

  • AW Logue (1985) ArticleTitleConditioned food aversion learning in humans Ann N Y Acad Sci 443 316–329 Occurrence Handle3860075 Occurrence Handle10.1111/j.1749-6632.1985.tb27082.x Occurrence Handle1:STN:280:DyaL2M3kvFyjuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • AW Logue KR Logue KE Strauss (1983) ArticleTitleThe acquisition of taste aversions in humans with eating and drinking disorders Behav Res Ther 21 275–289 Occurrence Handle6577856 Occurrence Handle10.1016/0005-7967(83)90210-3 Occurrence Handle1:STN:280:DyaL3szgvVClug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • WE Lyons LA Mamounas GA Ricaurte V Coppola SW Reid SH Bora C Wihler VE Koliatsos L Tessarollo (1999) ArticleTitleBrain-derived neurotrophic factor-deficient mice develop aggressiveness and hypophagia in conjunction with brain serotonergic abnormalities PNAS 96 15239–15244 Occurrence Handle10611369 Occurrence Handle10.1073/pnas.96.26.15239 Occurrence Handle1:CAS:528:DC%2BD3cXhtFejuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • CJ McClain MA Stuart B Vivian M McClain R Talwalker L Snelling L Humphries (1992) ArticleTitleZinc status before and after zinc supplementation of eating disorder patients J Am Coll Nutr 11 694–700 Occurrence Handle1460184 Occurrence Handle1:STN:280:DyaK3s%2FpsVClsw%3D%3D

    PubMed  CAS  Google Scholar 

  • IJ Miller (1986) ArticleTitleVariations in human fungiform taste bud densities among regions and subjects Anat Rec 216 474–482 Occurrence Handle3799995 Occurrence Handle10.1002/ar.1092160404

    Article  PubMed  Google Scholar 

  • IJ Miller FE Reedy (1990a) ArticleTitleQuantification of fungiform papillae and taste pores in living human subjects Chem Senses 15 281–294 Occurrence Handle10.1093/chemse/15.3.281

    Article  Google Scholar 

  • IJ Miller FE Reedy (1990b) ArticleTitleVariations in human taste bud density and taste intensity perception Physiol Behav 47 1213–1219 Occurrence Handle10.1016/0031-9384(90)90374-D

    Article  Google Scholar 

  • M Misra P Tsai EJ Anderson JL Hubbard K Gallagher LA Soyka KK Miller DB Herzog A Klibanski (2006) ArticleTitleNutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents Am J Clin Nutr 84 698–706 Occurrence Handle17023694 Occurrence Handle1:CAS:528:DC%2BD28XhtFWgtr3O

    PubMed  CAS  Google Scholar 

  • CM Mistretta H-X Liu W Gaffield DK MacCallum (2003) ArticleTitleCyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium Dev Biol 254 1–18 Occurrence Handle12606278 Occurrence Handle10.1016/S0012-1606(02)00014-3 Occurrence Handle1:CAS:528:DC%2BD3sXhsVCgsLk%3D

    Article  PubMed  CAS  Google Scholar 

  • JE Mitchell MP Mussell CB Peterson S Crow SA Wonderlich RD Crosby T Davis C Weller (1999) ArticleTitleHedonics of binge eating in women with bulimia nervosa and binge eating disorder Int J Eat Disord 26 165–170 Occurrence Handle10422605 Occurrence Handle10.1002/(SICI)1098-108X(199909)26:2<165::AID-EAT5>3.0.CO;2-H Occurrence Handle1:STN:280:DyaK1MzltFGjtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • P Monteleone M Fabrazzo V Martiadis C Serritella M Pannuto M Maj (2005) ArticleTitleCirculating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge-eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables Psychol Med 35 897–905 Occurrence Handle15997610 Occurrence Handle10.1017/S0033291704003368

    Article  PubMed  Google Scholar 

  • P Monteleone A Tortorella V Martiadis C Serritella A Fuschino M Maj (2004) ArticleTitleOpposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity Psychosom Med 66 744–748 Occurrence Handle15385700 Occurrence Handle10.1097/01.psy.0000138119.12956.99 Occurrence Handle1:CAS:528:DC%2BD2cXnsV2rt7o%3D

    Article  PubMed  CAS  Google Scholar 

  • C Mueller S Kallert B Renner K Stiassny AFP Temmel T Hummel G Kobal (2003) ArticleTitleQuantitative assessment of gustatory function in a clinical context using impregnated “taste strips” Rhinology 41 2–6 Occurrence Handle12677732 Occurrence Handle1:STN:280:DC%2BD3s7mtFChug%3D%3D

    PubMed  CAS  Google Scholar 

  • M Naganuma M Ikeda H Tomita (1988) ArticleTitleChanges in soft palate taste buds of rats due to aging and zinc deficiency – scanning electron microscopic observation Auris Nasus Larynx 15 117–127 Occurrence Handle3207412 Occurrence Handle1:STN:280:DyaL1M%2FoslCjtg%3D%3D

    PubMed  CAS  Google Scholar 

  • M Nakazato K Hashimoto E Shimizu C Kumakiri H Koizumi N Okamura M Mitsumori N Komatsu M Iyo (2003) ArticleTitleDecreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders Biol Psychiat 54 485–490 Occurrence Handle12915293 Occurrence Handle10.1016/S0006-3223(02)01746-8 Occurrence Handle1:CAS:528:DC%2BD3sXmt1aju7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • CA Nosrat (1998) ArticleTitleNeurotrophic factors in the tongue: expression patterns, biological activity, relation to innervation and studies of neurotrophin knockout mice Ann N Y Acad Sci 855 28–49 Occurrence Handle9929584 Occurrence Handle10.1111/j.1749-6632.1998.tb10544.x Occurrence Handle1:CAS:528:DyaK1MXmvFSktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • CA Nosrat A Ebendal L Olson (1996) ArticleTitleDifferential expression of brain-derived neurotrophic factor and neurotrophin 3 mRNA in lingual papillae and taste buds indicates roles in gustatory and somatosensory innervation J Comp Neurol 376 587–602 Occurrence Handle8978472 Occurrence Handle10.1002/(SICI)1096-9861(19961223)376:4<587::AID-CNE7>3.0.CO;2-Y Occurrence Handle1:CAS:528:DyaK2sXkslaksw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • S-I Nozoe A Masuda T Naruo Y Soejima N Nagai H Tanaka (1996) ArticleTitleChanges in taste responsiveness in patients with anorexia nervosa during behavior therapy Physiol Behav 59 549–553 Occurrence Handle8700959 Occurrence Handle10.1016/0031-9384(95)02105-1 Occurrence Handle1:CAS:528:DyaK28XhsVGrs7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • I Ohara R Tabuchi M Kimura Y Itokawa (1995) ArticleTitleDecline of taste sensitivity in protein deficient adult rats Physiol Behav 57 921–926 Occurrence Handle7610145 Occurrence Handle10.1016/0031-9384(94)00388-L Occurrence Handle1:CAS:528:DyaK2MXltVahu7w%3D

    Article  PubMed  CAS  Google Scholar 

  • J Prutkin VB Duffy L Etter K Fast E Gardner LA Lucchina DJ Snyder K Tie J Weiffenbach LM Bartoshuk (2000) ArticleTitleGenetic variation and inferences about perceived taste intensity in mice and men Physiol Behav 69 161–173 Occurrence Handle10854927 Occurrence Handle10.1016/S0031-9384(00)00199-2 Occurrence Handle1:CAS:528:DC%2BD3cXktVSmtbg%3D

    Article  PubMed  CAS  Google Scholar 

  • M Ribasés M Gratacòs L Armengol R de Cid A Badia L Jiménez R Solano J Vallejo F Fernández X Estivill (2003) ArticleTitleMet66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type Mol Psychiatr 8 745–751 Occurrence Handle10.1038/sj.mp.4001281 Occurrence Handle1:CAS:528:DC%2BD3sXlvVGjtL0%3D

    Article  CAS  Google Scholar 

  • M Ribasés M Gratacòs F Fernández-Aranda L Bellodi C Boni M Anderluh MC Cavallini E Cellini DD Bella S Erzegovesi C Foulon M Gabrovsek P Gorwood J Hebebrand A Hinney J Holliday X Hu A Karwautz A Kipman R Komel B Nacmias H Remschmidt V Ricca S Sorbi G Wagner J Treasure DA Collier Xl Estivill (2004) ArticleTitleAssociation of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations Hum Mol Genet 13 1205–1212 Occurrence Handle15115760 Occurrence Handle10.1093/hmg/ddh137

    Article  PubMed  Google Scholar 

  • M Ribasés M Gratacòs F Fernández-Aranda L Bellodi C Boni M Anderluh MC Cavallini E Cellini DD Bella S Erzegovesi C Foulon M Gabrovsek P Gorwood J Hebebrand A Hinney J Holliday X Hu A Karwautz A Kipman R Komel B Nacmias H Remschmidt V Ricca S Sorbi M Tomori G Wagner J Treasure DA Collier Xl Estivill (2005) ArticleTitleAssociation of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations Eur J Hum Genet 13 428–434 Occurrence Handle15657604 Occurrence Handle10.1038/sj.ejhg.5201351 Occurrence Handle1:CAS:528:DC%2BD2MXisFKitbs%3D

    Article  PubMed  CAS  Google Scholar 

  • J Rodin HR Moskowitz GA Bray (1976) ArticleTitleRelationship between obesity, weight loss, and taste responsiveness Physiol Behav 17 591–597 Occurrence Handle1013209 Occurrence Handle10.1016/0031-9384(76)90157-8 Occurrence Handle1:STN:280:DyaE2s7gtlWjtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • CB Saper TC Chou JK Elmquist (2002) ArticleTitleThe need to feed: homeostatic and hedonic control of eating Neuron 36 199–211 Occurrence Handle12383777 Occurrence Handle10.1016/S0896-6273(02)00969-8 Occurrence Handle1:CAS:528:DC%2BD38XotlansL8%3D

    Article  PubMed  CAS  Google Scholar 

  • C Segovia I Hutchinson DG Laing AL Jinks (2002) ArticleTitleA quantitative study of fungiform papillae and taste pore density in adults and children Dev Brain Res 138 135–146 Occurrence Handle10.1016/S0165-3806(02)00463-7 Occurrence Handle1:CAS:528:DC%2BD38Xnt1ais74%3D

    Article  CAS  Google Scholar 

  • M Shahbake I Hutchinson DG Laing AL Jinks (2005) ArticleTitleRapid quantitative assessment of fungiform papillae density in the human tongue Brain Res 1052 196–201 Occurrence Handle16051197 Occurrence Handle10.1016/j.brainres.2005.06.031 Occurrence Handle1:CAS:528:DC%2BD2MXns1Wmtrg%3D

    Article  PubMed  CAS  Google Scholar 

  • Y Simon F Bellise M-O Monneuse B Samuel-Lajeunesse A Drewnowski (1993) ArticleTitleTaste responsiveness in anorexia nervosa Br J Psychiatry 162 244–246 Occurrence Handle8435696 Occurrence Handle1:STN:280:DyaK3s7mvFertA%3D%3D Occurrence Handle10.1192/bjp.162.2.244

    Article  PubMed  CAS  Google Scholar 

  • P Södersten C Bergh M Zandian (2006) ArticleTitleUnderstanding eating disorders Horm Behav 50 572–578 Occurrence Handle16890228 Occurrence Handle10.1016/j.yhbeh.2006.06.030 Occurrence Handle1:CAS:528:DC%2BD28XptFCnsrc%3D

    Article  PubMed  CAS  Google Scholar 

  • SR Sunday A Einhorn KA Halmi (1992) ArticleTitleRelationship of perceived macronutrient and caloric content to affective cognitions about food in eating-disordered, restrained, and unrestrained subjects Am J Clin Nutr 55 362–371 Occurrence Handle1734673 Occurrence Handle1:STN:280:DyaK387jtlGgug%3D%3D

    PubMed  CAS  Google Scholar 

  • SR Sunday KA Halmi (1990) ArticleTitleTaste perceptions and hedonics in eating disorders Physiol Behav 48 587–594 Occurrence Handle2082356 Occurrence Handle10.1016/0031-9384(90)90196-B Occurrence Handle1:STN:280:DyaK3M7osl2nug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SR Sunday KA Halmi (1996) ArticleTitleMicro- and macroanalyses of patterns within a meal in anorexia and bulimia nervosa Appetite 26 21–36 Occurrence Handle8660030 Occurrence Handle10.1006/appe.1996.0002 Occurrence Handle1:STN:280:DyaK283jtV2jug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • SR Sunday KA Halmi (2003) ArticleTitleEnergy intake and body composition in anorexia and bulimia nervosa Physiol Behav 78 11–17 Occurrence Handle12536005 Occurrence Handle10.1016/S0031-9384(02)00879-X Occurrence Handle1:CAS:528:DC%2BD3sXkvFaiuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • R Tabuchi I Ohara (1996) ArticleTitleInfluence of zinc supplementation to diets at graded levels of protein on taste sensitivity, morphological changes of tongue epithelia and serum zinc concentration in growing rats J Am Coll Nutr 15 303–308 Occurrence Handle8935447 Occurrence Handle1:CAS:528:DyaK28XjvFyjtL8%3D

    PubMed  CAS  Google Scholar 

  • R Tabuchi I Ohara (1998) ArticleTitleThe timing of protein feeding and dietary protein levels affect taste preference, serum zinc concentration and glossal epithelial morphology in growing rats J Am Coll Nutr 17 79–85 Occurrence Handle9477395 Occurrence Handle1:CAS:528:DyaK1cXhtFSiu7k%3D

    PubMed  CAS  Google Scholar 

  • M Tanaka (2002) ArticleTitleSecretory function of the salivary gland in patients with taste disorders or xerostomia: correlation with zinc deficiency Acta Otolaryngol Suppl 546 134–141 Occurrence Handle12132611 Occurrence Handle10.1080/00016480260046526

    Article  PubMed  Google Scholar 

  • PP Tannhauser (2002) ArticleTitleAnorexia nervosa: a multifactorial disease of nutritional origin? Int J Adolesc Med Health 14 185–191 Occurrence Handle12467193

    PubMed  Google Scholar 

  • L Wöckel T Hummel FD Zepf A Jacob F Poustka (2007) ArticleTitleChanged taste perception in patients with eating disorders Z Kinder Jugendpsychiatr 35 423–434 Occurrence Handle10.1024/1422-4917.35.6.423

    Article  Google Scholar 

  • S Yanovski (2003) ArticleTitleSugar and fat: cravings and aversions J Nutr 133 835S–837S Occurrence Handle12612163 Occurrence Handle1:CAS:528:DC%2BD3sXhvFylu7o%3D

    PubMed  CAS  Google Scholar 

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  1. Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital, Frankfurt/Main, Germany

    L. Wöckel, A. Jacob, M. Holtmann & F. Poustka

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  1. L. Wöckel
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  2. A. Jacob
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  3. M. Holtmann
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  4. F. Poustka
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Correspondence to L. Wöckel.

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Correspondence: Lars Wöckel, Department of Child and Adolescent Psychiatry and Psychotherapy, Johann Wolfgang Goethe University Hospital Frankfurt, Deutschordenstr. 50, 60528 Frankfurt/Main, Germany

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Wöckel, L., Jacob, A., Holtmann, M. et al. Reduced number of taste papillae in patients with eating disorders. J Neural Transm 115, 537–544 (2008). https://doi.org/10.1007/s00702-007-0845-y

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  • DOI: https://doi.org/10.1007/s00702-007-0845-y

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