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Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson’s disease in Taiwan

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Summary

Inflammatory events may contribute to the pathogenesis of Parkinson’s disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1α C-889T and IL-1β C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1α-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22−0.88, p = 0.021) and the decrease is strengthened by IL-1β-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11−0.71, p = 0.008). Our data suggest that IL-1α, acting synergistically with IL-1β, plays role in PD susceptibility among Taiwanese people older than 70 years of age.

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Authors and Affiliations

  1. Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan

    Y. R. Wu, C. M. Chen & S. T. Chen

  2. Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

    J. C. Hwang, I. H. Feng, H. C. Hsu, C. N. Liu, Y. T. Liu, Y. Y. Lai, H. J. Huang & G. J. Lee-Chen

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Wu, Y., Chen, C., Hwang, J. et al. Interleukin-1α polymorphism has influence on late-onset sporadic Parkinson’s disease in Taiwan. J Neural Transm 114, 1173–1177 (2007). https://doi.org/10.1007/s00702-007-0726-4

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