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Adult neurogenesis in serotonin transporter deficient mice

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Summary

Serotonin (5-HT) is a regulator of morphogenetic activities during early brain development and neurogenesis, including cell proliferation, migration, differentiation, and synaptogenesis. The 5-HT transporter (5-HTT, SLC6A4) mediates high-affinity reuptake of 5-HT into presynaptic terminals and thereby fine-tunes serotonergic neurotransmission. Inactivation of the 5-HTT gene in mice reduces 5-HT clearance resulting in persistently increased concentrations of synaptic 5-HT. In the present study, we investigated the effects of elevated 5-HT levels on adult neurogenesis in the hippocampus of 5-HTT deficient mice, including stem cell proliferation, survival, and differentiation. Using an in vivo approach, we showed an increase in proliferative capacity of hippocampal adult neural stem cells in aged 5-HTT knockout mice (∼14.5 months) compared to wildtype controls. In contrast, in vivo and additional in vitro analyses of younger adult 5-HTT knockout mice (∼7 weeks and ∼3.0 months) did not reveal significant changes in proliferation of neural stem cells or survival of newborn cells. We showed that the cellular fate of newly generated cells in 5-HTT knockout mice is not different with respect to the total number and percentage of neurons or glial cells from wildtype controls. Our findings indicate that elevated synaptic 5-HT concentration throughout early development and later life of 5-HTT deficient mice does not induce adult neurogenesis in adult mice, but that elevated 5-HT levels in aged mice influence stem cell proliferation.

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References

  • MA Aberg ND Aberg H Hedbacker J Oscarsson PS Eriksson (2000) ArticleTitlePeripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus J Neurosci 20 IssueID8 2896–2903 Occurrence Handle1:CAS:528:DC%2BD3cXisVertLY%3D Occurrence Handle10751442

    CAS  PubMed  Google Scholar 

  • M Banasr M Hery JM Brezun A Daszuta (2001) ArticleTitleSerotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus Eur J Neurosci 14 IssueID9 1417–1424 10.1046/j.0953-816x.2001.01763.x Occurrence Handle10.1046/j.0953-816x.2001.01763.x Occurrence Handle1:STN:280:DC%2BD3Mnns12mtg%3D%3D Occurrence Handle11722603

    Article  CAS  PubMed  Google Scholar 

  • D Bengel DL Murphy AM Andrews CH Wichems D Feltner A Heils R Mossner H Westphal KP Lesch (1998) ArticleTitleAltered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice Mol Pharmacol 53 IssueID4 649–655 Occurrence Handle1:CAS:528:DyaK1cXislCgtL0%3D Occurrence Handle9547354

    CAS  PubMed  Google Scholar 

  • J Benninghoff A Schmitt R Mossner KP Lesch (2002) ArticleTitleWhen cells become depressed: focus on neural stem cells in novel treatment strategies against depression J Neural Transm 109 IssueID5–6 947–962 10.1007/s007020200078 Occurrence Handle10.1007/s007020200078 Occurrence Handle1:CAS:528:DC%2BD38XmtVCqtrg%3D Occurrence Handle12111481

    Article  CAS  PubMed  Google Scholar 

  • JM Brezun A Daszuta (1999) ArticleTitleDepletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats Neuroscience 89 IssueID4 999–1002 10.1016/S0306-4522(98)00693-9 Occurrence Handle10.1016/S0306-4522(98)00693-9 Occurrence Handle1:CAS:528:DyaK1MXhslWqt7c%3D Occurrence Handle10362289

    Article  CAS  PubMed  Google Scholar 

  • JM Brezun A Daszuta (2000) ArticleTitleSerotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats Hippocampus 10 IssueID1 37–46 10.1002/(SICI)1098-1063(2000)10:1<37::AID-HIPO4>3.0.CO;2-C Occurrence Handle10.1002/(SICI)1098-1063(2000)10:1<37::AID-HIPO4>3.0.CO;2-C Occurrence Handle1:CAS:528:DC%2BD3cXhs1yit7Y%3D Occurrence Handle10706215

    Article  CAS  PubMed  Google Scholar 

  • B Di Cara N Dusticier C Forni JC Lievens A Daszuta (2001) ArticleTitleSerotonin depletion produces long lasting increase in striatal glutamatergic transmission J Neurochem 78 IssueID2 240–248 10.1046/j.1471-4159.2001.00242.x Occurrence Handle10.1046/j.1471-4159.2001.00242.x Occurrence Handle1:CAS:528:DC%2BD3MXlsVeisbw%3D Occurrence Handle11461959

    Article  CAS  PubMed  Google Scholar 

  • G Di Pino R Mossner KP Lesch JM Lauder AM Persico (2004) ArticleTitleSerotonin roles in neurodevelopment: more than just neural transmission Curr Neuropharmacol 2 403–417 10.2174/1570159043359495 Occurrence Handle10.2174/1570159043359495 Occurrence Handle1:CAS:528:DC%2BD2cXnvFejtbk%3D

    Article  CAS  Google Scholar 

  • A Dranovsky R Hen (2006) ArticleTitleHippocampal neurogenesis: regulation by stress and antidepressants Biol Psychiatry 59 IssueID12 1136–1143 10.1016/j.biopsych.2006.03.082 Occurrence Handle10.1016/j.biopsych.2006.03.082 Occurrence Handle1:CAS:528:DC%2BD28XmtVOitr0%3D Occurrence Handle16797263

    Article  CAS  PubMed  Google Scholar 

  • A Dugar BJ Keck LW Maines S Miller R Njai JM Lakoski (2001) ArticleTitleCompensatory responses in the aging hippocampal serotonergic system following neurodegenerative injury with 5,7-dihydroxytryptamine Synapse 39 IssueID2 109–121 10.1002/1098-2396(200102)39:2<109::AID-SYN2>3.0.CO;2-B Occurrence Handle10.1002/1098-2396(200102)39:2<109::AID-SYN2>3.0.CO;2-B Occurrence Handle1:CAS:528:DC%2BD3MXpsFWk Occurrence Handle11180498

    Article  CAS  PubMed  Google Scholar 

  • RS Duman J Malberg S Nakagawa (2001a) ArticleTitleRegulation of adult neurogenesis by psychotropic drugs and stress J Pharmacol Exp Ther 299 IssueID2 401–407 Occurrence Handle1:CAS:528:DC%2BD3MXnvV2qsLs%3D

    CAS  Google Scholar 

  • RS Duman S Nakagawa J Malberg (2001b) ArticleTitleRegulation of adult neurogenesis by antidepressant treatment Neuropsychopharmacology 25 IssueID6 836–844 10.1016/S0893-133X(01)00358-X Occurrence Handle10.1016/S0893-133X(01)00358-X Occurrence Handle1:CAS:528:DC%2BD3MXpt1antL8%3D

    Article  CAS  Google Scholar 

  • JM Encinas A Vaahtokari G Enikolopov (2006) ArticleTitleFluoxetine targets early progenitor cells in the adult brain Proc Natl Acad Sci USA 103 IssueID21 8233–8238 10.1073/pnas.0601992103 Occurrence Handle10.1073/pnas.0601992103 Occurrence Handle1:CAS:528:DC%2BD28Xlt1Chtb0%3D Occurrence Handle16702546

    Article  CAS  PubMed  Google Scholar 

  • PS Eriksson E Perfilieva T Bjork-Eriksson AM Alborn C Nordborg DA Peterson FH Gage (1998) ArticleTitleNeurogenesis in the adult human hippocampus Nat Med 4 IssueID11 1313–1317 10.1038/3305 Occurrence Handle10.1038/3305 Occurrence Handle1:CAS:528:DyaK1cXntlaktb4%3D Occurrence Handle9809557

    Article  CAS  PubMed  Google Scholar 

  • V Fabre C Beaufour A Evrard A Rioux N Hanoun KP Lesch DL Murphy L Lanfumey M Hamon MP Martres (2000a) ArticleTitleAltered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter Eur J Neurosci 12 IssueID7 2299–2310 10.1046/j.1460-9568.2000.00126.x Occurrence Handle10.1046/j.1460-9568.2000.00126.x Occurrence Handle1:STN:280:DC%2BD3cvjtlemtg%3D%3D

    Article  CAS  Google Scholar 

  • V Fabre B Boutrel N Hanoun L Lanfumey CM Fattaccini B Demeneix J Adrien M Hamon MP Martres (2000b) ArticleTitleHomeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer J Neurosci 20 IssueID13 5065–5075 Occurrence Handle1:CAS:528:DC%2BD3cXksF2jt7k%3D

    CAS  Google Scholar 

  • T Frodl EM Meisenzahl P Zill T Baghai D Rujescu G Leinsinger R Bottlender C Schule P Zwanzger RR Engel R Rupprecht B Bondy M Reiser HJ Moller (2004) ArticleTitleReduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression Arch Gen Psychiatry 61 IssueID2 177–183 10.1001/archpsyc.61.2.177 Occurrence Handle10.1001/archpsyc.61.2.177 Occurrence Handle1:CAS:528:DC%2BD2cXhslGmur4%3D Occurrence Handle14757594

    Article  CAS  PubMed  Google Scholar 

  • FH Gage (2000) ArticleTitleStructural plasticity: cause, result, or correlate of depression Biol Psychiatry 48 IssueID8 713–714 10.1016/S0006-3223(00)01019-2 Occurrence Handle10.1016/S0006-3223(00)01019-2 Occurrence Handle1:STN:280:DC%2BD3crht1Sitg%3D%3D Occurrence Handle11063967

    Article  CAS  PubMed  Google Scholar 

  • R Galli R Fiocco L De Filippis L Muzio A Gritti S Mercurio V Broccoli M Pellegrini A Mallamaci AL Vescovi (2002) ArticleTitleEmx2 regulates the proliferation of stem cells of the adult mammalian central nervous system Development 129 IssueID7 1633–1644 Occurrence Handle1:CAS:528:DC%2BD38Xjt1eitrg%3D Occurrence Handle11923200

    CAS  PubMed  Google Scholar 

  • P Gaspar O Cases L Maroteaux (2003) ArticleTitleThe developmental role of serotonin: news from mouse molecular genetics Nat Rev Neurosci 4 IssueID12 1002–1012 10.1038/nrn1256 Occurrence Handle10.1038/nrn1256 Occurrence Handle1:CAS:528:DC%2BD3sXovFeit7s%3D Occurrence Handle14618156

    Article  CAS  PubMed  Google Scholar 

  • EM Goergen LA Bagay K Rehm JL Benton BS Beltz (2002) ArticleTitleCircadian control of neurogenesis J Neurobiol 53 IssueID1 90–95 10.1002/neu.10095 Occurrence Handle10.1002/neu.10095 Occurrence Handle12360586

    Article  PubMed  Google Scholar 

  • E Gould (1999) ArticleTitleSerotonin and hippocampal neurogenesis Neuropsychopharmacology 21 IssueIDSuppl 2 46S–51S Occurrence Handle1:CAS:528:DyaK1MXltVOntL0%3D Occurrence Handle10432488

    CAS  PubMed  Google Scholar 

  • A Gritti EA Parati L Cova P Frolichsthal R Galli E Wanke L Faravelli DJ Morassutti F Roisen DD Nickel AL Vescovi (1996) ArticleTitleMultipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor J Neurosci 16 IssueID3 1091–1100 Occurrence Handle1:CAS:528:DyaK28XmsVeksA%3D%3D Occurrence Handle8558238

    CAS  PubMed  Google Scholar 

  • C Gross X Zhuang K Stark S Ramboz R Oosting L Kirby L Santarelli S Beck R Hen (2002) ArticleTitleSerotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult Nature 416 IssueID6879 396–400 10.1038/416396a Occurrence Handle10.1038/416396a Occurrence Handle1:CAS:528:DC%2BD38XislantLo%3D Occurrence Handle11919622

    Article  CAS  PubMed  Google Scholar 

  • N Haddjeri P Blier C de Montigny (1998) ArticleTitleLong-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors J Neurosci 18 IssueID23 10150–10156 Occurrence Handle1:CAS:528:DyaK1cXnslyqsLc%3D Occurrence Handle9822768

    CAS  PubMed  Google Scholar 

  • FA Henn B Vollmayr (2004) ArticleTitleNeurogenesis and depression: etiology or epiphenomenon? Biol Psychiatry 56 IssueID3 146–150 10.1016/j.biopsych.2004.04.011 Occurrence Handle10.1016/j.biopsych.2004.04.011 Occurrence Handle15271582

    Article  PubMed  Google Scholar 

  • A Holmes DL Murphy JN Crawley (2002) ArticleTitleReduced aggression in mice lacking the serotonin transporter Psychopharmacology (Berl) 161 IssueID2 160–167 10.1007/s00213-002-1024-3 Occurrence Handle10.1007/s00213-002-1024-3 Occurrence Handle1:CAS:528:DC%2BD38Xlt1egtrg%3D

    Article  CAS  Google Scholar 

  • A Holmes DL Murphy JN Crawley (2003a) ArticleTitleAbnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression Biol Psychiatry 54 IssueID10 953–959 10.1016/j.biopsych.2003.09.003 Occurrence Handle10.1016/j.biopsych.2003.09.003 Occurrence Handle1:CAS:528:DC%2BD3sXptVGrtbs%3D

    Article  CAS  Google Scholar 

  • A Holmes RJ Yang KP Lesch JN Crawley DL Murphy (2003b) ArticleTitleMice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior Neuropsychopharmacology 28 IssueID12 2077–2088 Occurrence Handle1:CAS:528:DC%2BD3sXptFOrur0%3D

    CAS  Google Scholar 

  • BL Jacobs P Tanapat AJ Reeves E Gould (1998) ArticleTitleSerotonin stimulates the production of new hippocampal granule neurons via the 5HT1A receptor in the adult rat Soc Neurosci Abstr 24 1992

    Google Scholar 

  • G Kempermann (2002) ArticleTitleWhy new neurons? Possible functions for adult hippocampal neurogenesis J Neurosci 22 IssueID3 635–638 Occurrence Handle1:CAS:528:DC%2BD38XhtFygtLc%3D Occurrence Handle11826092

    CAS  PubMed  Google Scholar 

  • G Kempermann G Kronenberg (2003) ArticleTitleDepressed new neurons — adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression Biol Psychiatry 54 IssueID5 499–503 10.1016/S0006-3223(03)00319-6 Occurrence Handle10.1016/S0006-3223(03)00319-6 Occurrence Handle12946878

    Article  PubMed  Google Scholar 

  • HG Kuhn H Dickinson-Anson FH Gage (1996) ArticleTitleNeurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation J Neurosci 16 IssueID6 2027–2033 Occurrence Handle1:CAS:528:DyaK28XhvVGnsro%3D Occurrence Handle8604047

    CAS  PubMed  Google Scholar 

  • HG Kuhn J Winkler G Kempermann LJ Thal FH Gage (1997) ArticleTitleEpidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain J Neurosci 17 IssueID15 5820–5829 Occurrence Handle1:CAS:528:DyaK2sXkvFynu7o%3D Occurrence Handle9221780

    CAS  PubMed  Google Scholar 

  • JM Lauder (1993) ArticleTitleNeurotransmitters as growth regulatory signals: role of receptors and second messengers Trends Neurosci 16 IssueID6 233–240 10.1016/0166-2236(93)90162-F Occurrence Handle10.1016/0166-2236(93)90162-F Occurrence Handle1:CAS:528:DyaK3sXkvVKhsLc%3D Occurrence Handle7688165

    Article  CAS  PubMed  Google Scholar 

  • KP Lesch (2003) Neuroticism and serotonin: a developmental genetic perspective R Plomin J DeFries I Craig P McGuffin (Eds) Behavioral genetics in the postgenomic era American Psychiatric Press Washington, DC 389–423 BibChapterDOI10.1037/10480-020 Occurrence Handle10.1037/10480-020

    Chapter  Google Scholar 

  • KP Lesch DL Murphy (2003) Molecular genetics of transporters for norepinephrine, dopamine, and serotonin in behavioral traits and complex diseases S Broeer CA Wagner (Eds) Membrane transport diseases: molecular basis of inherited transport defects Kluwer Academic/Plenum New York

    Google Scholar 

  • KP Lesch D Bengel A Heils SZ Sabol BD Greenberg S Petri J Benjamin CR Müller DH Hamer DL Murphy (1996) ArticleTitleAssociation of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1527–1531 10.1126/science.274.5292.1527 Occurrence Handle10.1126/science.274.5292.1527 Occurrence Handle1:CAS:528:DyaK28Xnt1ansL8%3D Occurrence Handle8929413

    Article  CAS  PubMed  Google Scholar 

  • Q Li C Wichems A Heils KP Lesch DL Murphy (2000) ArticleTitleReduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences J Neurosci 20 IssueID21 7888–7895 Occurrence Handle1:CAS:528:DC%2BD3cXnsl2msbs%3D Occurrence Handle11050108

    CAS  PubMed  Google Scholar 

  • TM Madsen A Treschow J Bengzon TG Bolwig O Lindvall A Tingstrom (2000) ArticleTitleIncreased neurogenesis in a model of electroconvulsive therapy Biol Psychiatry 47 IssueID12 1043–1049 10.1016/S0006-3223(00)00228-6 Occurrence Handle10.1016/S0006-3223(00)00228-6 Occurrence Handle1:STN:280:DC%2BD3czit12ntQ%3D%3D Occurrence Handle10862803

    Article  CAS  PubMed  Google Scholar 

  • JE Malberg AJ Eisch EJ Nestler RS Duman (2000) ArticleTitleChronic antidepressant treatment increases neurogenesis in adult rat hippocampus J Neurosci 20 IssueID24 9104–9110 Occurrence Handle1:CAS:528:DC%2BD3MXis1SqsA%3D%3D Occurrence Handle11124987

    CAS  PubMed  Google Scholar 

  • GL Ming H Song (2005) ArticleTitleAdult neurogenesis in the mammalian central nervous system Annu Rev Neurosci 28 223–250 10.1146/annurev.neuro.28.051804.101459 Occurrence Handle10.1146/annurev.neuro.28.051804.101459 Occurrence Handle1:CAS:528:DC%2BD2MXosVegtLs%3D Occurrence Handle16022595

    Article  CAS  PubMed  Google Scholar 

  • C Mirescu E Gould (2006) ArticleTitleStress and adult neurogenesis Hippocampus 16 IssueID3 233–238 10.1002/hipo.20155 Occurrence Handle10.1002/hipo.20155 Occurrence Handle1:CAS:528:DC%2BD28XjtV2ktbk%3D Occurrence Handle16411244

    Article  CAS  PubMed  Google Scholar 

  • R Mossner A Schmitt T Hennig J Benninghoff M Gerlach P Riederer J Deckert KP Lesch (2004) ArticleTitleQuantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice J Neural Transm 111 IssueID1 27–35 10.1007/s00702-003-0074-y Occurrence Handle10.1007/s00702-003-0074-y Occurrence Handle1:STN:280:DC%2BD2c%2Fhs1Clsg%3D%3D Occurrence Handle14714213

    Article  CAS  PubMed  Google Scholar 

  • Y Pan E Gembom W Peng KP Lesch R Mossner R Simantov (2001) ArticleTitlePlasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice Brain Res Dev Brain Res 126 IssueID1 125–129 10.1016/S0165-3806(00)00145-0 Occurrence Handle10.1016/S0165-3806(00)00145-0 Occurrence Handle1:CAS:528:DC%2BD3MXhtFSks7s%3D Occurrence Handle11172895

    Article  CAS  PubMed  Google Scholar 

  • A Ravary A Muzerelle M Darmon DL Murphy R Moessner KP Lesch P Gaspar (2001) ArticleTitleAbnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein Eur J Neurosci 13 IssueID7 1349–1362 10.1046/j.0953-816x.2001.1511.x Occurrence Handle10.1046/j.0953-816x.2001.1511.x Occurrence Handle1:STN:280:DC%2BD3M3lsFSrsw%3D%3D Occurrence Handle11298795

    Article  CAS  PubMed  Google Scholar 

  • BA Reynolds W Tetzlaff S Weiss (1992) ArticleTitleA multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes J Neurosci 12 IssueID11 4565–4574 Occurrence Handle1:CAS:528:DyaK3sXhs12huw%3D%3D Occurrence Handle1432110

    CAS  PubMed  Google Scholar 

  • N Salichon P Gaspar AL Upton S Picaud N Hanoun M Hamon E De Maeyer DL Murphy R Mossner KP Lesch R Hen I Seif (2001) ArticleTitleExcessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice J Neurosci 21 IssueID3 884–896 Occurrence Handle1:CAS:528:DC%2BD3MXht1SjsrY%3D Occurrence Handle11157075

    CAS  PubMed  Google Scholar 

  • L Santarelli M Saxe C Gross A Surget F Battaglia S Dulawa N Weisstaub J Lee R Duman O Arancio C Belzung R Hen (2003) ArticleTitleRequirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 IssueID5634 805–809 10.1126/science.1083328 Occurrence Handle10.1126/science.1083328 Occurrence Handle1:CAS:528:DC%2BD3sXmtVGqsrY%3D Occurrence Handle12907793

    Article  CAS  PubMed  Google Scholar 

  • A Schmitt R Mossner A Gossmann IG Fischer V Gorboulev DL Murphy H Koepsell KP Lesch (2003) ArticleTitleOrganic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice J Neurosci Res 71 IssueID5 701–709 10.1002/jnr.10521 Occurrence Handle10.1002/jnr.10521 Occurrence Handle1:CAS:528:DC%2BD3sXitFWlsbs%3D Occurrence Handle12584728

    Article  CAS  PubMed  Google Scholar 

  • BW Scott JM Wojtowicz WM Burnham (2000) ArticleTitleNeurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures Exp Neurol 165 IssueID2 231–236 10.1006/exnr.2000.7458 Occurrence Handle10.1006/exnr.2000.7458 Occurrence Handle1:STN:280:DC%2BD3M%2FhtVOluw%3D%3D Occurrence Handle10993683

    Article  CAS  PubMed  Google Scholar 

  • T Seki Y Arai (1995) ArticleTitleAge-related production of new granule cells in the adult dentate gyrus Neuroreport 6 IssueID18 2479–2482 10.1097/00001756-199512150-00010 Occurrence Handle10.1097/00001756-199512150-00010 Occurrence Handle1:STN:280:DyaK28zkt12lsw%3D%3D Occurrence Handle8741746

    Article  CAS  PubMed  Google Scholar 

  • YI Sheline MH Gado HC Kraemer (2003) ArticleTitleUntreated depression and hippocampal volume loss Am J Psychiatry 160 IssueID8 1516–1518 10.1176/appi.ajp.160.8.1516 Occurrence Handle10.1176/appi.ajp.160.8.1516 Occurrence Handle12900317

    Article  PubMed  Google Scholar 

  • YI Sheline PW Wang MH Gado JG Csernansky MW Vannier (1996) ArticleTitleHippocampal atrophy in recurrent major depression Proc Natl Acad Sci USA 93 IssueID9 3908–3913 10.1073/pnas.93.9.3908 Occurrence Handle10.1073/pnas.93.9.3908 Occurrence Handle1:CAS:528:DyaK28XivVKrt7k%3D Occurrence Handle8632988

    Article  CAS  PubMed  Google Scholar 

  • HW Shen Y Hagino H Kobayashi K Shinohara-Tanaka K Ikeda H Yamamoto T Yamamoto KP Lesch DL Murphy FS Hall GR Uhl I Sora (2004) ArticleTitleRegional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters Neuropsychopharmacology 29 IssueID10 1790–1799 10.1038/sj.npp.1300476 Occurrence Handle10.1038/sj.npp.1300476 Occurrence Handle1:CAS:528:DC%2BD2cXnslSmtbk%3D Occurrence Handle15226739

    Article  CAS  PubMed  Google Scholar 

  • HJ Song CF Stevens FH Gage (2002) ArticleTitleNeural stem cells from adult hippocampus develop essential properties of functional CNS neurons Nat Neurosci 5 IssueID5 438–445 Occurrence Handle1:CAS:528:DC%2BD38XjtFyku74%3D Occurrence Handle11953752

    CAS  PubMed  Google Scholar 

  • Unger EL, Luellen BA, Lee O, Lyons WE, Blue ME, Mamounas LA, Andrews AM (2002) Decreased serotonin transporter expression prevents age-related serotonergic fiber loss in the forebrain. Society for Neuroscience, Orlando

  • H van Praag G Kempermann FH Gage (1999) ArticleTitleRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus Nat Neurosci 2 IssueID3 266–270 10.1038/6368 Occurrence Handle10.1038/6368 Occurrence Handle1:CAS:528:DyaK1MXhsl2gu7g%3D Occurrence Handle10195220

    Article  CAS  PubMed  Google Scholar 

  • H van Praag AF Schinder BR Christie N Toni TD Palmer FH Gage (2002) ArticleTitleFunctional neurogenesis in the adult hippocampus Nature 415 IssueID6875 1030–1034 10.1038/4151030a Occurrence Handle10.1038/4151030a Occurrence Handle1:CAS:528:DC%2BD38XhvVWjsbs%3D Occurrence Handle11875571

    Article  CAS  PubMed  Google Scholar 

  • T Vitalis C Alvarez K Chen JC Shih P Gaspar O Cases (2003) ArticleTitleDevelopmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives J Comp Neurol 464 IssueID3 392–403 10.1002/cne.10804 Occurrence Handle10.1002/cne.10804 Occurrence Handle1:CAS:528:DC%2BD3sXntlertLg%3D Occurrence Handle12900932

    Article  CAS  PubMed  Google Scholar 

  • DJ Walther M Bader (1999) ArticleTitleSerotonin synthesis in murine embryonic stem cells Brain Res Mol Brain Res 68 IssueID1–2 55–63 10.1016/S0169-328X(99)00046-7 Occurrence Handle10.1016/S0169-328X(99)00046-7 Occurrence Handle1:CAS:528:DyaK1MXjs1eitbc%3D Occurrence Handle10320783

    Article  CAS  PubMed  Google Scholar 

  • JL Warner-Schmidt RS Duman (2006) ArticleTitleHippocampal neurogenesis: opposing effects of stress and antidepressant treatment Hippocampus 16 IssueID3 239–249 10.1002/hipo.20156 Occurrence Handle10.1002/hipo.20156 Occurrence Handle1:CAS:528:DC%2BD28XjtV2ktbY%3D Occurrence Handle16425236

    Article  CAS  PubMed  Google Scholar 

  • PM Whitaker-Azmitia EC Azmitia (1994) ArticleTitleAstroglial 5-HT1a receptors and S-100 beta in development and plasticity Perspect Dev Neurobiol 2 IssueID3 233–238 Occurrence Handle1:CAS:528:DyaK2MXitlGls7c%3D Occurrence Handle7850356

    CAS  PubMed  Google Scholar 

  • M Wolff P Costet C Gross R Hen L Segu MC Buhot (2004) ArticleTitleAge-dependent effects of serotonin-1A receptor gene deletion in spatial learning abilities in mice Brain Res Mol Brain Res 130 IssueID1–2 39–48 10.1016/j.molbrainres.2004.07.012 Occurrence Handle10.1016/j.molbrainres.2004.07.012 Occurrence Handle1:CAS:528:DC%2BD2cXptFOlsb4%3D Occurrence Handle15519675

    Article  CAS  PubMed  Google Scholar 

  • P Wu YI Tarasenko Y Gu LY Huang RE Coggeshall Y Yu (2002) ArticleTitleRegion-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat Nat Neurosci 5 IssueID12 1271–1278 10.1038/nn974 Occurrence Handle10.1038/nn974 Occurrence Handle1:CAS:528:DC%2BD38XovFChs7g%3D Occurrence Handle12426573

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany

    A. Schmitt, R. Moessner, C. Doenitz, S. Gross, M. Hermann, S. Fritzen, A. Reif & K.-P. Lesch

  2. Stem Cell Research Institute, Ospedale S. Raffaele, Milan, Italy

    J. Benninghoff, M. Rizzi, A. Gritti & A. Vescovi

  3. Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Munich, Munich, Germany

    J. Benninghoff

  4. INSERM, U677, Université Pierre et Marie Curie, Paris, France

    E. Paizanis, L. Lanfumey & M. Hamon

  5. Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD, U.S.A

    D. L. Murphy

Authors
  1. A. Schmitt
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  2. J. Benninghoff
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  3. R. Moessner
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  4. M. Rizzi
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  5. E. Paizanis
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  6. C. Doenitz
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  7. S. Gross
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  8. M. Hermann
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  9. A. Gritti
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  10. L. Lanfumey
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  11. S. Fritzen
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  12. A. Reif
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  13. M. Hamon
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  14. D. L. Murphy
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  15. A. Vescovi
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  16. K.-P. Lesch
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Additional information

First two authors contributed equally to this work

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Schmitt, A., Benninghoff, J., Moessner, R. et al. Adult neurogenesis in serotonin transporter deficient mice. J Neural Transm 114, 1107–1119 (2007). https://doi.org/10.1007/s00702-007-0724-6

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  • DOI: https://doi.org/10.1007/s00702-007-0724-6

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