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Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer’s disease

  • Amine oxidases and disease
  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

One of the key pathological features of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is cerebral amyloid angiopathy (CAA). CAA is present in most cases of AD, and it is characterized by the deposition of β-amyloid (Aβ) in brain vessels, inducing the degeneration of vascular smooth muscle cells and endothelial cells. Herein we report that semicarbazide-sensitive amine oxidase (SSAO) is overexpressed in cerebrovascular tissue of patients with AD-CAA, and that it colocalizes with β-amyloid deposits. This over-expression correlates with high SSAO activity in plasma of severe AD patients. In addition, we have observed that the catalytic activity of SSAO is able to induce apoptosis in smooth muscle cells in vitro. Taken together, these results allow us to postulate that SSAO may contribute to the vascular damage associated to AD.

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Abbreviations

Aβ:

β-amyloid

AD:

Alzheimer’s disease

AGE:

advanced-glycation end products

CAA:

cerebral amyloid angiopathy

SSAO:

semicarbazide-sensitive amine oxidase

VAP-1:

vascular-adhesion protein 1

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Authors and Affiliations

  1. Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain

    M. Unzeta, M. Solé & M. Hernández

  2. Servei de Neurologia, Hospital Universitari Vall d’Hebron, Barcelona, Spain

    M. Boada

  3. Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain

    M. Boada

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  1. M. Unzeta
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  2. M. Solé
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  3. M. Boada
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  4. M. Hernández
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Unzeta, M., Solé, M., Boada, M. et al. Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer’s disease. J Neural Transm 114, 857–862 (2007). https://doi.org/10.1007/s00702-007-0701-0

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