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RGS4 genotype is not associated with antipsychotic medication response in schizophrenia

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Summary.

The aims of the present study were to compare the allele frequencies of a common single nucleotide polymorphism located upstream of the regulator of G-protein signaling 4 (RGS4) gene (T > G, Rs 951436) in 219 Finnish patients with schizophrenia and in 389 control subjects, to analyze corresponding frequencies between two different subtypes of 93 schizophrenia patients according to their medication response, and to study the effect of this SNP on age at onset in schizophrenia.

The RGS4 (T > G, Rs 951436) genotype was not associated with incidence or age at onset in schizophrenia. Neither was the RGS4 genotype associated with medication response with two different subpopulations with schizophrenia.

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Authors and Affiliations

  1. Medical School, University of Tampere, Tampere, Finland

    O. Kampman, A. Illi, S. Anttila, R. Rontu, K. M. Mattila, E. Leinonen & T. Lehtimäki

  2. Department of Psychiatry, Seinäjoki Hospital District, Finland

    O. Kampman

  3. Department of Psychiatry, Kanta-Häme Central Hospital, Finland

    A. Illi

  4. Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland

    S. Anttila, R. Rontu, K. M. Mattila & T. Lehtimäki

  5. Department of Psychiatry, Tampere University Hospital, Finland

    E. Leinonen

  6. Department of Psychiatry, South Karelia Central Hospital, Finland

    K. Hänninen

  7. Department of Psychiatry, Medical School and Helsinki University Central Hospital, University of Helsinki, Finland

    H. Katila

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  1. O. Kampman
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  2. A. Illi
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  3. K. Hänninen
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  5. S. Anttila
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  9. T. Lehtimäki
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Kampman, O., Illi, A., Hänninen, K. et al. RGS4 genotype is not associated with antipsychotic medication response in schizophrenia. J Neural Transm 113, 1563–1568 (2006). https://doi.org/10.1007/s00702-006-0445-2

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  • DOI: https://doi.org/10.1007/s00702-006-0445-2

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