Skip to main content
SpringerLink
Log in

Effects of stimulus-response compatibility in Parkinson’s disease: a psychophysiological analysis

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

The present study investigated the mechanisms underlying stimulus-response compatibility effects in Parkinson’s disease patients and matched controls. Since basal ganglia are involved in the selection and inhibition of competing responses we examined whether basal ganglia dysfunction in Parkinson’s disease leads to greater interference effects compared to the control subjects. Reaction times and lateralized movement-related cortical potentials (lateralized readiness potential: LRP) were recorded in two modified Eriksen flanker tasks.

Both groups were influenced by compatibility conditions; interference was seen as enhanced reaction time and error rate, as well as incorrect early LRP and delayed late LRP in incongruent trials. Altogether, behavioral and electrophysiological measures showed the interference to be rather smaller for the patients than for the controls. In contrast, facilitation did not differ among groups. Hence the claim that Parkinson’s disease patients are more influenced than controls by interfering directional stimuli appears not always valid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • GE Alexander MD Crutcher (1990) ArticleTitleFunctional architecture of basal ganglia circuits: neural substrates of parallel processing Trends Neurosci 109 266–271 Occurrence Handle10.1016/0166-2236(90)90107-L

    Article  Google Scholar 

  • GE Alexander MR DeLong PL Strick (1986) ArticleTitleParallel organization of functionally segregated circuits linking basal ganglia and cortex Annu Rev Neurosci 9 357–381 Occurrence Handle3085570 Occurrence Handle1:STN:280:BimB3MzmslU%3D Occurrence Handle10.1146/annurev.ne.09.030186.002041

    Article  PubMed  CAS  Google Scholar 

  • AL Benton (1968) ArticleTitleDifferential behavioral effects in frontal lobe disease Neuropsychologia 6 53–60 Occurrence Handle10.1016/0028-3932(68)90038-9

    Article  Google Scholar 

  • RG Brown M Jahanshahi CD Marsden (1993) ArticleTitleResponse choice in Parkinson’s disease. The effects of uncertainty and stimulus-response compatibility Brain 116 869–885 Occurrence Handle8353713

    PubMed  Google Scholar 

  • RG Brown C Marsden (1988) ArticleTitleInternal versus external cues and the control of attention in Parkinson’s disease Brain 111 323–345 Occurrence Handle3378139

    PubMed  Google Scholar 

  • P Brown CD Marsden (1998) ArticleTitleWhat do the basal ganglia do? Lancet 351 1801–1804 Occurrence Handle9635969 Occurrence Handle1:STN:280:DyaK1c3pslyqsA%3D%3D Occurrence Handle10.1016/S0140-6736(97)11225-9

    Article  PubMed  CAS  Google Scholar 

  • G Chevalier JM Deniau (1990) ArticleTitleDisinhibition as a basic process in the expression of striatal functions Trends Neurosci 13 277–280 Occurrence Handle1695403 Occurrence Handle1:STN:280:By%2BA38%2Fgs1c%3D Occurrence Handle10.1016/0166-2236(90)90109-N

    Article  PubMed  CAS  Google Scholar 

  • MGH Coles (1989) ArticleTitleModern mind-brain reading: psychophysiology, physiology, and cognition Psychophysiology 26 251–269 Occurrence Handle2667018 Occurrence Handle1:STN:280:BiaA3s7nvVY%3D

    PubMed  CAS  Google Scholar 

  • BA Eriksen CW Eriksen (1974) ArticleTitleEffects of noise letters upon the identification of a nonsearch task Percept Psychophys 16 143–149

    Google Scholar 

  • CW Eriksen DW Schultz (1979) ArticleTitleInformation processing in visual search: a continuous flow conception and experimental results Percept Psychophys 25 249–263 Occurrence Handle461085 Occurrence Handle1:STN:280:CSaB38zitFQ%3D

    PubMed  CAS  Google Scholar 

  • S Fahn RL Elton InstitutionalAuthorNameMembers of the UPDRS Development Committee (1987) Unified Parkinson’s Disease Rating Scale S Fahn CD Marsden DB Calne M Goldstein (Eds) Recent developments in Parkinson’s disease Macmillan Healthcare Information Florham Park, NJ 153–163

    Google Scholar 

  • JH Flowers (1990) ArticleTitlePriming effects in perceptual classification Percept Psychophys 47 135–148 Occurrence Handle2304812 Occurrence Handle1:STN:280:By%2BC2MbosVA%3D

    PubMed  CAS  Google Scholar 

  • G Gratton MGH Coles E Donchin (1983) ArticleTitleA new method for off-line removal of ocular artifact Electroencephalogr Clin Neurophysiol 55 468–484 Occurrence Handle6187540 Occurrence Handle1:STN:280:BiyC2MjjtFA%3D Occurrence Handle10.1016/0013-4694(83)90135-9

    Article  PubMed  CAS  Google Scholar 

  • A Henik J Singh DJ Beckley RD Rafal (1993) ArticleTitleDisinhibition of automatic word reading in Parkinson’s disease Cortex 29 589–599 Occurrence Handle8124936 Occurrence Handle1:STN:280:ByuC2s%2FmtFA%3D

    PubMed  CAS  Google Scholar 

  • S Jackson G Houghton (1995) Sensorimotorselection and the basal ganglia: a neural network model JG Houk JL Davis DG Beiser (Eds) Models of information processing in the basal ganglia IVIT Press Cambridge 337–374

    Google Scholar 

  • DL Jones JL Bradshaw JG Phillips R Iansek JB Mattingley JA Bradshaw (1994) ArticleTitleAllocation of attention to programming of movement sequences in Parkinson’s disease J Clin Exp Neuropsychol 16 117–128 Occurrence Handle8150882 Occurrence Handle1:STN:280:ByuB3c7ivFU%3D

    PubMed  CAS  Google Scholar 

  • AJ Jurkowski SA Hackley G Gratton (2002) ArticleTitleDissociation of age and Parkinson’s disease effects in a response conflict. Society for Psychophysiological Research. Abstracts, Forty-Second Annual Meeting, Washington, DC Psychophysiology 39 8

    Google Scholar 

  • F Karayanidis (1989) ArticleTitleParkinson’s disease: a conceptualization of neuropsychological deficits within an information-processing framework Biol Psychol 29 149–179 Occurrence Handle2697379 Occurrence Handle1:STN:280:By%2BC1c7ls1Q%3D Occurrence Handle10.1016/0301-0511(89)90035-5

    Article  PubMed  CAS  Google Scholar 

  • B Kopp F Rist U Mattler (1996) ArticleTitleN200 in the flanker task as a neurobehavioral tool for investigating executive control Psychophysiology 33 282–294 Occurrence Handle8936397 Occurrence Handle1:STN:280:ByiD1M%2FkvV0%3D

    PubMed  CAS  Google Scholar 

  • S Kornblum T Hasbroucq A Osman (1990) ArticleTitleDimensional overlap: cognitive basis for stimulus-response compatibility – a model and taxonomy Psychol Rev 97 253–270 Occurrence Handle2186425 Occurrence Handle1:STN:280:By%2BB2crpt1Q%3D Occurrence Handle10.1037/0033-295X.97.2.253

    Article  PubMed  CAS  Google Scholar 

  • SS Lee K Wild C Hollnagel J Grafman (1999) ArticleTitleSelective visual attention in patients with frontal lobe lesions or Parkinson’s disease Neuropsychologia 37 595–604 Occurrence Handle10340318 Occurrence Handle1:STN:280:DyaK1M3ntFKktQ%3D%3D Occurrence Handle10.1016/S0028-3932(98)00081-5

    Article  PubMed  CAS  Google Scholar 

  • KA Low J Miller E Vierck (2002) ArticleTitleResponse slowing in Parkinson’s disease. A psychophysiological analysis of premotor and motor processes Brain 125 1980–1994 Occurrence Handle12183344 Occurrence Handle10.1093/brain/awf206

    Article  PubMed  Google Scholar 

  • WT Maddox JV Filoteo DC Delis DP Salmon (1996) ArticleTitleVisual selective attention deficits in Patients with Parkinson’s disease: a quantitative model-based approach Neuropsychology 10 197–218 Occurrence Handle10.1037/0894-4105.10.2.197

    Article  Google Scholar 

  • U Mattler (2003) ArticleTitleDelayed flanker effects in lateralized readiness potentials Exp Brain Res 151 272–288 Occurrence Handle12739092 Occurrence Handle10.1007/s00221-003-1486-5

    Article  PubMed  Google Scholar 

  • J Miller T Patterson R Ulrich (1998) ArticleTitleJackknife-based method for measuring LRP onset latency differences Psychophysiology 35 99–115 Occurrence Handle9499711 Occurrence Handle1:STN:280:DyaK1c7mtVKqsg%3D%3D Occurrence Handle10.1017/S0048577298000857

    Article  PubMed  CAS  Google Scholar 

  • JW Mink (1996) ArticleTitleThe basal ganglia: focused selection and inhibition of competing motor programs Prog Neurobiol 50 381–425 Occurrence Handle9004351 Occurrence Handle1:STN:280:ByiC2MfgslY%3D Occurrence Handle10.1016/S0301-0082(96)00042-1

    Article  PubMed  CAS  Google Scholar 

  • HE Nelson (1976) ArticleTitleA modified card sorting test sensitive to frontal lobe defect Cortex 12 313–324 Occurrence Handle1009768 Occurrence Handle1:STN:280:CSiD1M%2FivF0%3D

    PubMed  CAS  Google Scholar 

  • P Praamstra EM Plat AS Meyer MWIM Horstink (1999) ArticleTitleMotor cortex activation in Parkinson’s disease: dissociation of electrocortical and peripheral measures of response generation Mov Disord 14 790–799 Occurrence Handle10495040 Occurrence Handle1:STN:280:DyaK1Mvitlagsw%3D%3D Occurrence Handle10.1002/1531-8257(199909)14:5<790::AID-MDS1011>3.0.CO;2-A

    Article  PubMed  CAS  Google Scholar 

  • P Praamstra DF Stegeman AR Cools MWIM Horstink (1998) ArticleTitleReliance on external cues for movement initiation in Parkinson’s disease. Evidence from movement-related potentials Brain 121 167–177 Occurrence Handle9549497 Occurrence Handle10.1093/brain/121.1.167

    Article  PubMed  Google Scholar 

  • MH Sharpe (1990) ArticleTitleDistractibility in early Parkinson’s disease Cortex 26 239–246 Occurrence Handle2387158 Occurrence Handle1:STN:280:By%2BA2M3pvFc%3D

    PubMed  CAS  Google Scholar 

  • MH Sharpe (1992) ArticleTitleAuditory attention in early Parkinson’s disease: an impairment in focused attention Neuropsychologia 30 101–106 Occurrence Handle1738465 Occurrence Handle1:STN:280:By2C2cbnvVw%3D Occurrence Handle10.1016/0028-3932(92)90019-I

    Article  PubMed  CAS  Google Scholar 

  • W Sommer R Ulrich H Leuthold (1996) ArticleTitleDas Lateralisierte Bereitschaftspotential als psychophysiologischer Zugang bei der Untersuchung kognitiver Prozesse Psychol Rundschau 47 1–14

    Google Scholar 

  • E Wascher M Reinhard B Wauschkuhn R Verleger (1999) ArticleTitleSpatial S-R compatibility with centrally presented stimuli: an event-related asymmetry study on dimensional overlap J Cogn Neurosci 11 214–229 Occurrence Handle10198136 Occurrence Handle1:STN:280:DyaK1M3hsVGiuw%3D%3D Occurrence Handle10.1162/089892999563346

    Article  PubMed  CAS  Google Scholar 

  • E Wascher R Verleger P Vieregge P Jaskowski S Koch D Kömpf (1997) ArticleTitleResponses to cued signals in Parkinson’s disease. Distinguishing between disorders of cognition and of activation Brain 120 1355–1375 Occurrence Handle9278628 Occurrence Handle10.1093/brain/120.8.1355

    Article  PubMed  Google Scholar 

  • R Willemssen J Hoormann J Hohnsbein M Falkenstein (2004) ArticleTitleCentral and parietal event-related lateralizations in a flanker task Psychophysiology 41 762–771 Occurrence Handle15318882 Occurrence Handle10.1111/j.1469-8986.2004.00201.x

    Article  PubMed  Google Scholar 

  • SA Wylie JC Stout TR Bashore (2005) ArticleTitleActivation of conflicting responses in Parkinson’s disease: evidence for degrading and facilitating effects on response time Neuropsychologia 43 1033–1043 Occurrence Handle15769489 Occurrence Handle10.1016/j.neuropsychologia.2004.10.008

    Article  PubMed  Google Scholar 

  • EJ Zeef A Kok (1993) ArticleTitleAge-related differences in the timing of stimulus and response processes during visual selective attention: performance and psychophysiological analyses Psychophysiology 30 138–151 Occurrence Handle8434077 Occurrence Handle1:STN:280:ByyC28rosVY%3D

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany

    M. Falkenstein, R. Willemssen & J. Hohnsbein

  2. Neurologische Klinik mit klinischer Neurophysiologie, Evangelisches Krankenhaus Gelsenkirchen, Gelsenkirchen, Germany

    H. Hielscher

Authors
  1. M. Falkenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Willemssen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Hohnsbein
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Hielscher
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Falkenstein, M., Willemssen, R., Hohnsbein, J. et al. Effects of stimulus-response compatibility in Parkinson’s disease: a psychophysiological analysis. J Neural Transm 113, 1449–1462 (2006). https://doi.org/10.1007/s00702-005-0430-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00702-005-0430-1

Search

Navigation