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Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population

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Summary.

Eating disorders (EDs) have a highly heterogeneous etiology and multiple genetic factors might contribute to their pathogenesis. Ghrelin, a novel growth hormone-releasing peptide, enhances appetite and increases food intake, and human ghrelin plasma levels are inversely correlated with body mass index. In the present study, we examined the 171T/C polymorphism of the ghrelin receptor (growth hormone secretagogue receptor, GHSR) gene in patients diagnosed with EDs, because the subjects having ghrelin gene polymorphism (Leu72Met) was not detected in a Japanese population, previously. In addition, β3 adrenergic receptor gene polymorphism (Try64Arg) and cholecystokinin (CCK)-A receptor (R) gene polymorphism (−81A/G, −128G/T), which are both associated with obesity, were investigated. The subjects consisted of 228 Japanese patients with EDs [96 anorexia nervosa (AN), 116 bulimia nervosa (BN) and 16 not otherwise specified (NOS)]. The age- and gender-matched control group consisted of 284 unrelated Japanese subjects. The frequency of the CC type of the GHSR gene was significantly higher in BN subjects than in control subjects (χ2 = 4.47, p = 0.035, odds ratio = 2.05, Bonferroni correction: p = 0.070), while the frequency in AN subjects was not different from that in controls. The distribution of neither β3 adrenergic receptor gene nor CCK-AR polymorphism differed between EDs and control subjects. Therefore, the CC type of GHSR gene polymorphism (171T/C) is a risk factor for BN, but not for AN.

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Authors and Affiliations

  1. Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

    K. Miyasaka, H. Hosoya, A. Sekime & M. Ohta

  2. Department of Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

    H. Amono

  3. National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Japan

    S. Matsushita, K. Suzuki & S. Higuchi

  4. Department of Gastroenterology, Kyushu Cancer Center, Fukuoka, Japan

    A. Funakoshi

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  1. K. Miyasaka
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  2. H. Hosoya
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  3. A. Sekime
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  4. M. Ohta
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  5. H. Amono
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  6. S. Matsushita
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  7. K. Suzuki
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  8. S. Higuchi
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  9. A. Funakoshi
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Miyasaka, K., Hosoya, H., Sekime, A. et al. Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population. J Neural Transm 113, 1279–1285 (2006). https://doi.org/10.1007/s00702-005-0393-2

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  • DOI: https://doi.org/10.1007/s00702-005-0393-2

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