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Kinematic analysis of dopaminergic effects on skilled handwriting movements in Parkinson’s disease

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Summary.

Patients with Parkinson’s disease (PD) exhibit impairments in the execution of highly practiced and skilled motor actions such as handwriting. The analysis of kinematic aspects of handwriting movements has demonstrated that size, speed, acceleration and stroke duration are affected in PD. Although beneficial effects of dopaminergic therapy in regard to execution of movements have been reported, the effects of pharmacological therapy on these measures have not been examined in detail. The present study has compared kinematic aspects of handwriting movements of 27 healthy subjects and 27 patients with PD both on their usual dopaminergic treatment and following withdrawal of dopaminergic medication. Healthy subjects were matched with PD patients according to age, sex, handedness and education level. A digitising tablet was used for the assessment of handwriting movements. Subjects were asked to perform a simple writing task. Movement time, distance, velocity, acceleration and measures of fluency of handwriting movements were measured. Compared with healthy subjects, the kinematics of handwriting movements in PD patients were markedly disturbed following withdrawal of dopaminergic medication. Although dopaminergic treatment in PD patients resulted in marked improvements in the kinematics of handwriting movements, PD patients did not reach an undisturbed level of performance. The results suggest that dopamine medication results in partial restoration of automatic movement execution.

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References

  • GE Alexander MR DeLong PL Strick (1986) ArticleTitleParallel organization of functionally segregated circuits linking basal ganglia and cortex Annu Rev Neurosci 9 357–381 Occurrence Handle10.1146/annurev.ne.09.030186.002041 Occurrence Handle3085570 Occurrence Handle1:STN:280:DyaL283htlKksw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • Anderson CE, Fisher MP (1999) Signatures of persons with parkinsonism and hepatic encephalopathy as comparison standards. In: Leedham CG, Leung M, Sagar V, Xuhong X (eds) Proceedings, Ninth Biennial Conference of the International Graphonomics Society. Nanyang Technological University, Singapore, pp 15–18

  • R Benecke JC Rothwell JPR Dick BL Day CD Marsden (1987) ArticleTitleDisturbance of sequential movements in patients with Parkinson’s disease Brain 110 361–379 Occurrence Handle3567527

    PubMed  Google Scholar 

  • R Blank V Miller H von Voss R von Kries (1999) ArticleTitleEffects of age on distally and proximally generated drawing movements: a kinematic analysis of school children and adults Dev Med Child Neurol 41 592–596 Occurrence Handle10.1017/S0012162299001243 Occurrence Handle10503917 Occurrence Handle1:STN:280:DyaK1MvjtFansA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • Bradshaw JL, Mattingley JB (1995) Clinical neuropsychology. Behavioral and brain science. Academic Press, London

  • RG Brown CD Marsden (1988) ArticleTitleInternal versus external cues and the control of attention in Parkinson’s disease Brain 111 323–345 Occurrence Handle3378139

    PubMed  Google Scholar 

  • Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd ed. Erlbaum, Hillsdale

  • J Contreras-Vidal GE Stelmach (1996) ArticleTitleEffects of Parkinsonism on motor control Life Sci 58 165–176 Occurrence Handle10.1016/0024-3205(95)02237-6 Occurrence Handle9499157 Occurrence Handle1:STN:280:DyaK287nvFartw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • JL Contreras-Vidal HL Teulings GE Stelmach (1998) ArticleTitleElderly subjects are impaired in spatial coordination in fine motor control Acta Psychol 100 25–35 Occurrence Handle10.1016/S0001-6918(98)00023-7 Occurrence Handle1:STN:280:DyaK1M%2FmtVGntg%3D%3D

    Article  CAS  Google Scholar 

  • DeLong MR (1993) Overview of basal ganglia function. In: Mano N, Hamada I, DeLong MR (eds) Role of the cerebellum and basal ganglia in voluntary movement. Elsevier, Amsterdam, pp 65–70

  • EH Dooijes (1983) ArticleTitleAnalysis of handwriting movements Acta Psychol 54 99–114 Occurrence Handle10.1016/0001-6918(83)90026-4

    Article  Google Scholar 

  • TE Eichhorn T Gasser N Mai C Marquardt G Arnold J Schwarz WH Oertel (1996) ArticleTitleComputational analysis of open loop handwriting movements in Parkinson’s disease: a rapid method to detect dopaminetic effects Mov Disord 11 289–297 Occurrence Handle10.1002/mds.870110313 Occurrence Handle8723147 Occurrence Handle1:STN:280:DyaK28zgtVCqtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • T Flash R Inzelberg E Schechtman AD Korsczyn (1997) ArticleTitleKinematic analysis of upper limb trajectories in Parkinson’s disease Exp Neurol 118 215–226 Occurrence Handle10.1016/0014-4886(92)90038-R

    Article  Google Scholar 

  • KA Flowers (1975) ArticleTitleBallistic and corrective movements on an aiming task: intention tremor and parkinsonian movement disorders compared Neurology 25 413–421 Occurrence Handle1169700 Occurrence Handle1:STN:280:DyaE2M7nsFeqsQ%3D%3D

    PubMed  CAS  Google Scholar 

  • KA Flowers (1976) ArticleTitleVisual “closed-loop” and “open-loop” characteristics of voluntary movement in patients with Parkinsonism and intention tremor Brain 99 269–310 Occurrence Handle990899 Occurrence Handle1:STN:280:DyaE2s%2Fks1GhtQ%3D%3D

    PubMed  CAS  Google Scholar 

  • N Georgiou R Iansek JL Bradshaw JG Phillips JB Mattingley JA Bradshaw (1993) ArticleTitleAn evaluation of the role of internal cues in the pathogenesis of parkinsonian hypokinesia Brain 116 1575–1587 Occurrence Handle8293289

    PubMed  Google Scholar 

  • G Goldberg (1985) ArticleTitleSupplementary motor area structure and function: review and hypotheses Behav Brain Res 8 567–588 Occurrence Handle10.1017/S0140525X00045167

    Article  Google Scholar 

  • LJ Gross (1975) ArticleTitleDrug-induced handwriting changes: an empirical review Tex Rep Biol Med 33 371–390 Occurrence Handle1:CAS:528:DyaE28XkslWrurY%3D

    CAS  Google Scholar 

  • M Hallett S Khoshbin (1980) ArticleTitleA physiological mechanism of bradykinesia Brain 103 301–314 Occurrence Handle7397480 Occurrence Handle1:STN:280:DyaL3c3ktlCluw%3D%3D

    PubMed  CAS  Google Scholar 

  • B Haslinger P Erhard N Kaempfe H Boecker E Rummeny M Schwaiger B Conrad AO Ceballos-Baumann (2001) ArticleTitleEvent-related functional magnetic resonance imaging in Parkinson’s disease before and after levodopa Brain 124 558–570 Occurrence Handle10.1093/brain/124.3.558 Occurrence Handle11222456 Occurrence Handle1:STN:280:DC%2BD3M7ps1ChtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • MM Hoehn MD Yahr (2001) ArticleTitleParkinsonism: onset, progression and mortality Neurology 57 IssueID[Suppl 3] 11–26

    Google Scholar 

  • AJ Hughes SE Daniel L Kilford AJ Lees (1992) ArticleTitleAccuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases J Neurol Neurosurg Psychiatry 55 181–184 Occurrence Handle1564476 Occurrence Handle1:STN:280:DyaK383is1Omsg%3D%3D

    PubMed  CAS  Google Scholar 

  • SR Jackson GM Jackson J Harrison L Henderson C Kennard (1995) ArticleTitleThe internal control of action and Parkinson’s disease: a kinematic analysis of visual-guided and memory-guided movements Exp Brain Res 105 147–162 Occurrence Handle10.1007/BF00242190 Occurrence Handle7589311 Occurrence Handle1:STN:280:DyaK28%2FmtFCjtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Jahanshahi IH Jenkins RG Brown CD Marsden RE Passingham DJ Brooks (1995) ArticleTitleSelf-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson’s disease subjects Brain 118 913–933 Occurrence Handle7655888

    PubMed  Google Scholar 

  • IH Jenkins DJ Brooks PD Nixon RS Frackowiak RE Passingham (1994) ArticleTitleMotor sequence learning: a study with positron emission tomography J Neurosci 14 3775–3790 Occurrence Handle8207487 Occurrence Handle1:STN:280:DyaK2c3mslGgtg%3D%3D

    PubMed  CAS  Google Scholar 

  • IH Jenkins W Fernandez ED Playford AJ Lees RS Frackowiak RE Passingham DJ Brooks (1992) ArticleTitleImpaired activation of the supplementary motor area in Parkinson’s disease is reversed when akinesia is treated with apomorphine Ann Neurol 32 749–757 Occurrence Handle10.1002/ana.410320608 Occurrence Handle1471865 Occurrence Handle1:STN:280:DyaK3s7htFKquw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • IH Jenkins M Jahanshahi M Jueptner RE Passingham DJ Brooks (2000) ArticleTitleSelf-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow Brain 123 1216–1228 Occurrence Handle10.1093/brain/123.6.1216 Occurrence Handle10825359

    Article  PubMed  Google Scholar 

  • M Jueptner KM Stephan CD Frith DJ Brooks R-SJ Frackowiak RE Passingham (1997) ArticleTitleAnatomy of motor learning. I. Frontal cortex and attention to action J Neurophysiol 77 1313–1324 Occurrence Handle9084599 Occurrence Handle1:STN:280:DyaK2s3jvVakuw%3D%3D

    PubMed  CAS  Google Scholar 

  • HL Klawans (1986) ArticleTitleIndividual manifestations of Parkinson’s disease after ten or more years of levodopa Mov Disord 1 187–192 Occurrence Handle10.1002/mds.870010304 Occurrence Handle3504244 Occurrence Handle1:STN:280:DyaL1M%2Fls12mtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • J Konczak H Ackermann I Hertrich S Spieker J Dichgans (1997) ArticleTitleControl of repetitive lip and finger movements in Parkinson’s disease: influence of external timing signals and simultaneous execution on motor performance Mov Disord 12 665–676 Occurrence Handle10.1002/mds.870120507 Occurrence Handle9380046 Occurrence Handle1:STN:280:DyaK1c%2FhslGnsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • KW Lange GM Paul M Naumann W Gsell (1995) ArticleTitleDopaminergic effects on cognitive performance in patients with Parkinson’s disease J Neural Transm [Suppl] 46 423–432 Occurrence Handle1:CAS:528:DyaK28XitVKhurw%3D

    CAS  Google Scholar 

  • KW Lange GM Paul TW Robbins CD Marsden (1993) ArticleTitleL-dopa and frontal cognitive function in Parkinson’s disease Adv Neurol 60 475–478 Occurrence Handle8420173 Occurrence Handle1:STN:280:DyaK3s7ivVSksQ%3D%3D

    PubMed  CAS  Google Scholar 

  • KW Lange TW Robbins CD Marsden M James AM Owen GM Paul (1992) ArticleTitleL-dopa withdrawal in Parkinson’s disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction Psychopharmacology 107 394–404 Occurrence Handle10.1007/BF02245167 Occurrence Handle1615139 Occurrence Handle1:CAS:528:DyaK38XksVShurY%3D

    Article  PubMed  CAS  Google Scholar 

  • PA Lewitt (1983) ArticleTitleMicrographia is a focal sign of neurological disease J Neurol Neurosurg Psychiatry 46 1152–1157 Occurrence Handle6663316 Occurrence Handle1:STN:280:DyaL2c7htlOnsg%3D%3D

    PubMed  CAS  Google Scholar 

  • MG Longstaff RA Heath (1997) ArticleTitleSpace-time invariance in adult handwriting Acta Psychol 97 201–214 Occurrence Handle10.1016/S0001-6918(97)00015-2

    Article  Google Scholar 

  • Longstaff MG, Mahant PR, Stacy MA, Van Gemmert AW, Leis BC, Stelmach GE (2001) Continuously scaling a continuous movement: Parkinsonian patients choose a smaller scaling ratio and produce more variable movements compared to elderly controls. In: Meulenbroeck RGJ, Steenbergen B (eds) Proceedings, Tenth Biennial Conference of the International Graphonomics Society. International Graphonomics Society, Nijmegen, pp 84–89

  • CJ Lueck S Tanyeri TJ Crawford L Henderson C Kennard (1990) ArticleTitleAntisaccades and remembered saccades in Parkinson’s disease J Neurol Neurosurg Psychiatry 53 284–288 Occurrence Handle2341840 Occurrence Handle1:STN:280:DyaK3c3lslKisQ%3D%3D

    PubMed  CAS  Google Scholar 

  • Mai N, Marquardt C (1992) CS – Computer-assisted movement analysis in handwriting. Operational manual. MedCom Verlag, Munich

  • C Malapani B Pillon B Dubois Y Agid (1994) ArticleTitleImpaired simultaneous cognitive task performance in Parkinson’s disease: a dopamine-related dysfunction Neurology 44 319–326 Occurrence Handle8309583 Occurrence Handle1:STN:280:DyaK2c7kt12itQ%3D%3D

    PubMed  CAS  Google Scholar 

  • DI Margolin AM Wing (1983) ArticleTitleAgraphia and micrographia: clinical manifestations of motor programming and performance disorders Acta Psychol 54 263–283 Occurrence Handle10.1016/0001-6918(83)90039-2 Occurrence Handle1:STN:280:DyaL2c7isVeqsA%3D%3D

    Article  CAS  Google Scholar 

  • C Marquardt N Mai (1994) ArticleTitleA computational procedure for movement analysis in handwriting J Neurosci Methods 52 39–45 Occurrence Handle10.1016/0165-0270(94)90053-1 Occurrence Handle8090015 Occurrence Handle1:STN:280:DyaK2czns1Crtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • CD Marsden (1982) ArticleTitleThe mysterious motor function of the basal ganglia Neurology 32 514–539 Occurrence Handle7200209 Occurrence Handle1:STN:280:DyaL387ntlGgtQ%3D%3D

    PubMed  CAS  Google Scholar 

  • JE McLennan K Nakano HR Tyler RS Schwab (1972) ArticleTitleMicrographia in Parkinson’s disease J Neurol Sci 15 141–152 Occurrence Handle10.1016/0022-510X(72)90002-0 Occurrence Handle5010101 Occurrence Handle1:STN:280:DyaE387isFCntA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • R Mergl P Tigges A Schroter HJ Moller U Hegerl (1999) ArticleTitleDigitized analysis of handwriting and drawing movements in healthy subjects: methods, results and perspectives J Neurosci Methods 90 157–169 Occurrence Handle10.1016/S0165-0270(99)00080-1 Occurrence Handle10513598 Occurrence Handle1:STN:280:DyaK1MvktFOmtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • RG Meulenbroek AJ Thomassen (1991) ArticleTitleStroke-direction preferences in drawing and handwriting Hum Mov Sci 10 247–270 Occurrence Handle10.1016/0167-9457(91)90006-J

    Article  Google Scholar 

  • Meulenbroek RGJ, Van Galen GP (1988) The acquisition of skilled handwriting: discontinuous trends in kinematic variables. In: Colley A, Beech J (eds) Cognition and action in skilled behaviour. Elsevier, North-Holland, pp 273–281

  • Meulenbroek RGJ, Van Galen GP (1989) The production of connecting strokes in cursive writing: developing co-articulation in 8 to 12 year-old children. In: Plamondon R, Suen CY, Simner ML (eds) Computer recognition and human production of handwriting. World Scientific Publishing, Singapore, pp 273–286

  • ME Morris R Iansek TA Matyas JJ Summers (1996) ArticleTitleStride length regulation in Parkinson’s disease: normalization strategies and underlying mechanisms Brain 119 551–568 Occurrence Handle8800948

    PubMed  Google Scholar 

  • Muller F, Stelmach GE (1992) Prehension movements in Parkinson’s disease. In: Stelmach GE, Requin J (eds) Tutorials in motor behavior II. Elsevier, Amsterdam, pp 307–319

  • RM Oliveira JM Gurd P Nixon JC Marshall RE Passingham (1997) ArticleTitleMicrographia in Parkinson’s disease: the effect of providing external cues J Neurol Neurosurg Psychiatry 63 429–433 Occurrence Handle9343118 Occurrence Handle1:STN:280:DyaK1c%2FgtFarsQ%3D%3D Occurrence Handle10.1136/jnnp.63.4.429

    Article  PubMed  CAS  Google Scholar 

  • RM Oliveira JM Gurd P Nixon JC Marshall RE Passingham (1998) ArticleTitleHypopmetria in Parkinson’s disease: automatic versus controlled processing Mov Disord 13 422–427 Occurrence Handle10.1002/mds.870130309 Occurrence Handle9613732 Occurrence Handle1:STN:280:DyaK1c3ntlOrug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • RE Passingham (1988) ArticleTitlePremotor cortex and preparation of movement Exp Brain Res 70 590–596 Occurrence Handle10.1007/BF00247607 Occurrence Handle3384057 Occurrence Handle1:STN:280:DyaL1c3lsFahsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • Passingham RE (1993) The frontal lobes and voluntary action. Oxford University Press, Oxford

  • Pedhazur EJ, Pedhazur Schmelkin L (1991) Meaurement, design, and analysis. An integrated approach. Lawrence Erlbaum, Hillsdale, NJ

  • JG Phillips GE Stelmach N Teasdale (1991) ArticleTitleWhat can indices of handwriting quality can tell us about Parkinsonian handwriting? Hum Mov Sci 10 301–314 Occurrence Handle10.1016/0167-9457(91)90009-M

    Article  Google Scholar 

  • ED Playford IH Jenkins RE Passingham J Nutt RS Frackowiak DJ Brooks (1992) ArticleTitleImpaired mesial frontal and putamen activation in Parkinson’s disease: a positron emission tomography study Ann Neurol 32 151–161 Occurrence Handle10.1002/ana.410320206 Occurrence Handle1510355 Occurrence Handle1:STN:280:DyaK38znvVWgsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • N Raoux O Benoit N Dantchev P Denise B Franc JF Allilaire D Widlöcher (1994) ArticleTitleCircadian pattern of motor activity in major depressed patients undergoing antidepressant therapy: relationship between actigraphic measures and clinical course Psychiatry Res 52 85–98 Occurrence Handle10.1016/0165-1781(94)90122-8 Occurrence Handle8047624 Occurrence Handle1:STN:280:DyaK2czitlClug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • M Samuel BA Ceballos J Blin T Uema H Boecker RE Passingham DJ Brooks (1997) ArticleTitleEvidence for lateral premotor and parietal overactivity in Parkinson’s disease during sequential and bimanual movements. A PET study Brain 120 963–976 Occurrence Handle10.1093/brain/120.6.963 Occurrence Handle9217681

    Article  PubMed  Google Scholar 

  • R Sandyk RP Iacono (1994) ArticleTitleReversal of micrographia in Parkinson’s disease by application of picotesla range magnetic fields Int J Neurosci 77 77–84 Occurrence Handle7989163 Occurrence Handle1:STN:280:DyaK2M%2FotV2jtQ%3D%3D Occurrence Handle10.3109/00207459408986020

    Article  PubMed  CAS  Google Scholar 

  • HR Siebner A Ceballos-Baumann H Standhardt C Auer B Conrad F Alesch (1999) ArticleTitleChanges in handwriting resulting from bilateral high-frequency stimulation of the subthalamic nucleus in Parkinson’s disease Mov Disord 14 964–971 Occurrence Handle10.1002/1531-8257(199911)14:6<964::AID-MDS1009>3.0.CO;2-C Occurrence Handle10584671 Occurrence Handle1:STN:280:DC%2BD3c%2FkvFeltA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • MJ Slavin JG Phillips JL Bradshaw (1996) ArticleTitleVisual cues and the handwriting of older adults: a kinematic analysis Psychol Aging 11 521–526 Occurrence Handle10.1037/0882-7974.11.3.521 Occurrence Handle8893319 Occurrence Handle1:STN:280:DyaK2s%2FkvVCrsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • MJ Slavin JG Phillips JL Bradshaw KA Hall I Presnell (1999) ArticleTitleConsistency of handwriting movements in dementia of the Alzheimer’s type: a comparison with Huntington’s and Parkinson’s diseases J Int Neuropsychol Soc 5 20–25 Occurrence Handle10.1017/S135561779951103X Occurrence Handle9989020 Occurrence Handle1:STN:280:DyaK1M7ktlGltw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • P Soliveri RG Brown CD Marsden (1992) ArticleTitleEffect of practice on performance of a skilled motor task in patients with Parkinson’s disease J Neurol Neurosurg Psychiatry 55 454–460 Occurrence Handle1619411 Occurrence Handle1:STN:280:DyaK38zhsl2gsg%3D%3D Occurrence Handle10.1136/jnnp.55.6.454

    Article  PubMed  CAS  Google Scholar 

  • SP Swinnen L Van-Langendonk S Verschueren G Peeters R Dom W De-Weerdt (1997) ArticleTitleInterlimb coordination deficits in patients with Parkinson’s disease during the production of two-joint oscillations in the sagittal plane Mov Disord 12 958–968 Occurrence Handle10.1002/mds.870120619 Occurrence Handle9399221 Occurrence Handle1:STN:280:DyaK1c%2FmtFKiuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • Teulings H-L (1986) The elementary units of programming in handwriting. In: Kao HSR, Van Galen GP, Hoosain R (eds) Graphonomics: contemporary research in handwriting. Elsevier, Amsterdam, pp 21–34

  • HL Teulings GE Stelmach (1991) ArticleTitleControl of stroke size, peak acceleration, and stroke duration in parkinsonian handwriting Hum Mov Sci 10 315–334 Occurrence Handle10.1016/0167-9457(91)90010-U

    Article  Google Scholar 

  • HL Teulings AJWM Thomassen (1979) ArticleTitleComputer-aided analysis of handwriting movements Visible Language 13 218–231

    Google Scholar 

  • H-L Teulings J Contreras-Vidal GE Stelmach CH Adler (1997) ArticleTitleParkinsonism reduces coordination of fingers, wrist and arm in fine motor control Exp Neurol 146 159–170 Occurrence Handle10.1006/exnr.1997.6507 Occurrence Handle9225749 Occurrence Handle1:STN:280:DyaK2szmvFalsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • AJWM Thomassen HL Teulings (1983) ArticleTitleConstancy in stationary and progressive handwriting Acta Psychol 54 179–196 Occurrence Handle10.1016/0001-6918(83)90032-X

    Article  Google Scholar 

  • Thomassen AJWM, Teulings H-L (1985) Time, size, and shape in handwriting: exploring spatio-temporal relationships at different levels. In: Michon JA, Jackson JB (eds) Time, mind, and behaviour. Springer, Berlin Heidelberg New York, pp 253–263

  • Thomassen AJWM, Van Galen GP (1992) Handwriting as a motor task: experimentation, modelling, and simulation. In: Summers JJ (ed) Approaches to the study of motor control and learning. North-Holland, Amsterdam, pp 113–144

  • O Tucha S Aschenbrenner P Eichhammer A Putzhammer H Sartor HE Klein KW Lange (2002) ArticleTitleThe impact of tricyclic antidepressants and selective serotonin re-uptake inhibitors on handwriting movements of patients with depression Psychopharmacology 159 211–215 Occurrence Handle10.1007/s002130100921 Occurrence Handle11862351 Occurrence Handle1:CAS:528:DC%2BD38XisVKlurg%3D

    Article  PubMed  CAS  Google Scholar 

  • O Tucha S Aschenbrenner KW Lange (2000) ArticleTitleMirror writing and handedness Brain and Language 73 432–441 Occurrence Handle10.1006/brln.2000.2316 Occurrence Handle10860564 Occurrence Handle1:STN:280:DC%2BD3czpt1Gntw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • Tucha O, Paul G, Lange KW (2001) The effect of conscious control on handwriting fluency of healthy adults and children. In: Meulenbroek RG, Steenbergen B (eds) Proceedings, Tenth Biennial Conference of the International Graphonomics Society. IGS, Nijmegen, pp 213–216

  • GP Van Galen (1991) ArticleTitleHandwriting: issues for a psychomotor theory Hum Mov Sci 10 165–191 Occurrence Handle10.1016/0167-9457(91)90003-G

    Article  Google Scholar 

  • Van Gemmert AW, Adler CH, Stelmach GE (2001) The isochronic size range is reduced in handwriting of parkinsonian patients. In: Meulenbroeck RGJ, Steenbergen B (eds) Proceedings, Tenth Biennial Conference of the International Graphonomics Society. International Graphonomics Society, Nijmegen, pp 36–39

  • Van Gemmert AW, Teulings H-L, Stelmach GE (1999) Parkinsonian patients reduce their stroke size with increased programming load. In: Leedham CG, Leung M, Sagar V, Xuhong X (eds) Proceedings, Ninth Biennial Conference of the International Graphonomics Society. Nanyang Technological University, Singapore, pp 231–236

  • A Vinter P Gras (1998) ArticleTitleSpatial features of angular drawing movements in Parkinson’s disease patients Acta Psychol 100 177–193 Occurrence Handle10.1016/S0001-6918(98)00033-X Occurrence Handle1:STN:280:DyaK1M%2FmtVGmtg%3D%3D

    Article  CAS  Google Scholar 

  • J Walton (1997) ArticleTitleHandwriting changes due to aging and Parkinson’s syndrome Forensic Sci Int 88 197–214 Occurrence Handle10.1016/S0379-0738(97)00105-9 Occurrence Handle9291592 Occurrence Handle1:STN:280:DyaK2svjs12hug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • P Weiss GE Stelmach H Hefter (1997) ArticleTitleProgramming of a movement sequence in Parkinson’s disease Brain 120 91–102 Occurrence Handle10.1093/brain/120.1.91 Occurrence Handle9055800

    Article  PubMed  Google Scholar 

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  1. Department of Experimental Psychology, University of Regensburg, Germany

    O. Tucha, L. Mecklinger, A. Reiter, G. L. Alders, H. Sartor & K. W. Lange

  2. Department of Psychiatry, School of Medicine, University of Wales Swansea, United Kingdom

    J. Thome

  3. Department of Neurology, University of Würzburg, Germany

    M. Naumann

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Tucha, O., Mecklinger, L., Thome, J. et al. Kinematic analysis of dopaminergic effects on skilled handwriting movements in Parkinson’s disease. J Neural Transm 113, 609–623 (2006). https://doi.org/10.1007/s00702-005-0346-9

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